Study to Evaluate the Efficacy of Percutaneous Cryoablation for Renal Tumours < 4cm in Patients Who Are Not Candidates for Partial Nephrectomy

Inclusion Criteria:

Patients should have the following characteristics:

* About 75 years, or
* Whatever the age:

  * A context of family-type tumor (VHL, hereditary carcinoma, tubulo-papillary ...);
  * or solitary kidney, when the tumor is not easily accessible for nephron-sparing surgery: Malignant centro-hilar or intra-parenchymal;
  * or in a local recurrence (single or multiple) after partial nephrectomy (within a limit of 3 tumors to be treated);
  * or in a subject with impaired renal function and therefore at risk of severe renal insufficiency (risk defined by a creatinine clearance below 30 ml / min by MDRD formula);
  * and who do not present any contra-indication for cryoablation treatment.

The tumor(s) should meet the following criteria:

* Presence of one to three solid tumors of the native renal parenchyma with a largest diameter less than (or equal to) 40 mm, which corresponds to a maximum volume of about 32 cc, as measured by MRI.
* A preoperative MRI is essential since this technique presents a higher sensitivity. This control will also give more consistency to the evaluation of the radiological semiology at follow-up.
* And its/their location(s) will be accessible to a percutaneous approach.

The search of metastases, including a thoracic CT scan, should be negative.

Exclusion Criter ia:

* \- Partial nephrectomy feasible in good technical and oncologic conditions in patients under 75 years and in the absence of family tumors.
* Contraindication to any form of sedation.
* Irreversible coagulopathy
* Tumor\> 4cm
* Contraindication to MRI or gadolinium (proven allergy). NB: Patients with a glomerular filtration rate below 30 ml/min/1, 73 m2 will be injected with a single dose of the macrocyclic gadolinium with the highest thermodynamic stability (Dotarem or Prohance), given the united recommendations of AFSSAPS and EMA (European Medicines Agency) \[45\]. On the contrary, the linear molecules of gadolinium, due to their lower stability, will be contra-indicated because of the risk of systemic nephrogenic fibrosis (FNS).
* Recurrence on the same location after a procedure performed out of the thermoablation protocol.
* Biopsy proven benign tumor
* Predominantly cystic tumor, defined by a necrotic content constituting over one third of tumor volume
* Presence of endo-venous extension, of proven secondary extensions, visceral or in the lymph nodes (especially lung). In this regard, a thoracic CT scan will be routinely required before treatment, according to the recommendations of urological societies.
* Psychiatric disorders and adults under guardianship
* Pregnancy or breastfeeding
* Minor patients
* Legal safeguard
* Participation in another clinical trial