Clinical trial · Interventional
CUP Project PET/CT
The Value of Early PET/CT in Patients With Metastasising Cancer of Unknown Primary
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose is to elucidate the value of PET/CT applied early in the work-up of patients with a metastasising cancer of an unknown primary tumor. The management of patients with metastasising cancer of unknown primary often includes various and a large number of radiographic studies and invasive procedures, but the occult primary tumor is detected in less than 20%. Early PET/CT may be useful in Cancer of Unknown Primary (CUP) before expensive and invasive diagnostic procedures are carried out. The outcome may be higher tumor detection rate and quicker diagnosis, avoiding unnecessary, extensive procedures. Furthermore, a large number of the patients will receive treatment aimed at the correct diagnosis. Therefore, a prospective cost-effectiveness analysis is warranted.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Metastasising Cancer of Unknown Primary | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| PET/CT or Conventional diagnostics including CT | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Early PET/CT
- interventionNames
- Radiation: PET/CT or Conventional diagnostics including CT
- type
- ACTIVE_COMPARATOR
- label
- Conventional diagnostics including CT
- interventionNames
- Radiation: PET/CT or Conventional diagnostics including CT
Primary outcomes (1)
- measure
- 1. Detection of primary tumor possible: yes/no (primary endpoint)
- timeFrame
- Up to 24 hours
- description
- The outcome is evaluated based on the project specified PET/CT compared to conventional diagnostic investigations including CT. - The evaluation of the PET/CT scan, primary tumor/non-primary tumor, is obtained by consensus of two nuclear medicine physicians with experience in PET/CT.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Biopsy proven cancer without identified origin at the time of examination. 2. Patients admitted to but not fitting into existing cancer package programs. 3. Patients with very serious, but unknown, disease, which might be cancer. Exclusion Criteria: 1. Patient belongs to one of the existing cancer packages - state which one. 2. Suspected metastasis in the liver. 3. Suspected metastasis in the brain. 4. Prior PET/CT imaging showing multiple metastases with no identifiable primary. 5. Cancer treatment already started. 6. Estimated inability to collaborate - state reason. 7. Prior malignant disease. 8. Pregnancy. 9. The patient cannot read and understand Danish.
References
Publications (0)
Data not yet available