Clinical trial · Interventional
Efficacy and Safety Study of Concurrent Chemoradiation Therapy to Treat Locally Advanced Cervical Cancer
Comparison of Concurrent Chemoradiation Therapy With Weekly Cisplatin and Concurrent Chemoradiation Therapy With Weekly Carboplatin in Locally Advanced Cervical Cancer: Phase III Multicenter Prospective Randomized Controlled Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Because of very slow rate of enrollement
Summary
Brief summary (as posted)
Concurrent chemoradiation therapy with weekly cisplatin is the current standard treatment for patients with locally advanced cervical cancer. However, weekly cisplatin is related to renal toxicity and not convenient regimen. Recently, carboplatin has proved to be a good radiosensitizer and less renal toxicity. Weekly carboplatin is more convenient regimen for both patients and physicians. Weekly carboplatin may have similar efficacy with weekly cisplatin and may have more favorable toxicity profile. Therefore, the investigators aimed to evaluate the efficacy and safety of concurrent chemoradiation with weekly carboplatin in patients with locally advanced cervical cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cervical Cancer | Malignant Cervical Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Carboplatin | Drug | Carboplatin | ALIAS |
| Cisplatin | Drug | Cisplatin | ALIAS |
| Radiation therapy | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- CCRT weekly carboplatin
- description
- Concurrent chemoradiation therapy with weekly carboplatin
- interventionNames
- Radiation: Radiation therapy
- Drug: Carboplatin
- type
- ACTIVE_COMPARATOR
- label
- CCRT weekly cisplatin
- description
- Concurrent chemoradiation therapy with weekly cisplatin
- interventionNames
- Radiation: Radiation therapy
- Drug: Cisplatin
Primary outcomes (1)
- measure
- Response rate
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 20 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Previously untreated, histologically confirmed cervical cancer * One of following histologic types Squamous carcinoma, adenocarcinoma, adenosquamous carcinoma * Age: 20-75 years * GOG performance status: 0-2 * Adequate organ function Bone marrow: WBC ≥ 3,000/mm3, ANC ≥ 1,500/mm3, Platelet ≥ 100X103/mm3, Hb ≥ 10.0 g/dl Kidney: Creatinine \< 1.25 × UNL, Liver : AST, ALT \< 3 × UNL, T- bilirubin \< 1.5 mg/ mm3 * Contraception during study treatment * Informed consent Exclusion Criteria: * Previous chemotherapy or pelvic radiation therapy * Hormone therapy within 4 weeks * Concomitant malignancy within 5 years except cured basal cell carcinoma of skin * Uncontrolled medical disease * Pregnant or lactating woman * Etc.
References
Publications (0)
Data not yet available