Hypofractionated Image-Guided Radiation Therapy (IGRT) in Patients With Stage II-III Non-Small Cell Lung Cancer

Inclusion Criteria:

* All patients must be willing and capable to provide informed consent to participate in the protocol.
* Patients must have appropriate staging studies identifying them as AJCC stage II or III non small cell lung cancer, (according to AJCC Staging, 6th edition; see appendix III), or recurrent non small cell lung cancer. Histologic confirmation of cancer will be required by biopsy or cytology within 6 months of study entry.
* Patients must have the potential for benefit from local therapy (at the discretion of the investigator).
* The patient's Zubrod performance status must be 2 or greater OR patients with Zubrod performance status 0-1 and weight loss \>10% are considered eligible. In addition, patients determined to be medically unfit or refusing combined modality therapy are eligible.
* Age ≥ 18.
* Patients must have measurable or evaluable disease.
* Women of childbearing potential and male participants must agree to use an effective method of contraception.
* Patients must sign study specific informed consent prior to study entry.
* Patients must not have plans for concurrent chemoradiation therapy.
* Patients must complete all required pretreatment evaluations

Exclusion Criteria:

* Total (aggregate) gross tumor volume \> 500 cm3 (500 cc's or 0.5 Liters)
* Prior radiotherapy to the region of the study cancer that would result in direct overlap of radiation therapy fields.
* Chemotherapy given within one week of study registration.
* Pregnant or lactating women, as treatment involves unforeseeable risks to the embryo or fetus.