Clinical trial · Interventional
Acupuncture to Treat Insulin Resistance in Women With and Without Polycystic Ovary Syndrome
Effect of Acupuncture on Insulin Sensitivity in Women With and Without Polycystic Ovary Syndrome
NCT01457209CI-TRIAL-00013530PCOS-AcupIRcompletedPhase 1ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The central hypothesis is that acupuncture break the vicious circle of androgen excess and reverse insulin resistance and improve health related quality of life and affective symptoms in overweight and obese women with and without Polycystic Ovary Syndrome.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Insulin Resistance | — | UNRESOLVED | — |
| Polycystic Ovary Syndrome | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Acupuncture | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Change in insulin sensitivity
- timeFrame
- Day 1 and Week 5
- description
- glucose disposal rate measured by euglycemic hyperinsulinemic clamp.
Secondary outcomes (4)
- measure
- Change in insulin signaling (muscle and adipose tissue)
- timeFrame
- Day 1 and Week 5
- description
- Western blot, RT-PCR
- measure
- Change in health related quality of life
- timeFrame
- Day 1 and Week 5
- description
- PCOSQ, SF36
- measure
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 38 Years
Show eligibility criteria text
Inclusion Criteria: * BMI \> 25 to \< 35 and * Clinical signs of hyperandrogenism (hirsutism or acne) and * At least one of the following two signs; oligo/amenorrhea and/or ultrasound-verified polycystic ovaries Controls should have BMI \> 25 to \< 35, regular cycles with 28 days ± 2 days, no signs of hyperandrogenism. Exclusion Criteria: Exclusion criteria for all women 1. Age \> 38 years 2. Exclusion of other endocrine disorders such as hyperprolactinemia (s-prolactin \< 27µg/L), nonclassic congenital adrenal hyperplasia (17-hydroxyprogesterone \< 3nmol/L), and androgen secreting tumors. 3. Autoimmune disorders, cancer, Type I diabetes and Type 2 diabetes. 4. Pharmacological treatment (cortisone, antidepressant, antidiabetic, hormonal contraceptives, hormonal ovulation induction or other drugs judged by discretion of investigator) within 12 wks accounts for all participants. 5. Blood pressure \>160 / 100 mmHg 6. Pregnancy or breastfeeding the last 6 months 7. Acupuncture last 2 months 8. Language barrier or disabled person with reduced ability to understand information.
References
Publications (3)
- DERIVEDBenrick A, Pillon NJ, Nilsson E, Lindgren E, Krook A, Ling C, Stener-Victorin E. Electroacupuncture Mimics Exercise-Induced Changes in Skeletal Muscle Gene Expression in Women With Polycystic Ovary Syndrome. J Clin Endocrinol Metab. 2020 Jun 1;105(6):2027-41. doi: 10.1210/clinem/dgaa165. PMID 32232327
- DERIVEDNilsson E, Benrick A, Kokosar M, Krook A, Lindgren E, Kallman T, Martis MM, Hojlund K, Ling C, Stener-Victorin E. Transcriptional and Epigenetic Changes Influencing Skeletal Muscle Metabolism in Women With Polycystic Ovary Syndrome. J Clin Endocrinol Metab. 2018 Dec 1;103(12):4465-4477. doi: 10.1210/jc.2018-00935. PMID 30113663
- DERIVEDZheng Y, Stener-Victorin E, Ng EH, Li J, Wu X, Ma H. How does acupuncture affect insulin sensitivity in women with polycystic ovary syndrome and insulin resistance? Study protocol of a prospective pilot study. BMJ Open. 2015 May 3;5(4):e007757. doi: 10.1136/bmjopen-2015-007757. PMID 25941189