Efficacy of Gemcitabine With Pazopanib as Second Line Treatment in Patient With Metastatic or Relapsed Uterine

Inclusion Criteria:

* Histologically confirmed diagnosis of metastatic or relapsed of uterine or soft tissue leiomyosarcoma previously treated with one line of chemotherapy with at least an anthracycline. Patients who have received adjuvant therapy less than one year before relapse were considered to have received a first line therapy for metastatic disease)
* Delay between the end of previous treatment (chemotherapy, hormonotherapy, radiotherapy, immunotherapy, surgery or tumor embolisation) must be \> 4 weeks
* At least one measurable lesion with RECIST criteria with progressive disease between the last 6 weeks between inclusion. One target at least must be in a non irradiated area
* performance status ECOG ≤ 2
* Age ≥ 18 years
* Subjects must provide written informed consent prior to performance of study-specific procedures, and must be willing to comply with treatment and follow up
* Adequate hematologic function
* Adequate coagulation function
* Adequate renal function
* Adequate liver function
* Patients must be affiliated to a Social Health Insurance
* Women of childbearing potential must be using a medically accepted method of contraception and must have a negative serum pregnancy test within 14 days of enrollment and/or urine pregnancy test 72 hours prior to the administration of the first study treatment.
* LVEF ≥ site limits

Main Exclusion Criteria:

* Other uterine or soft tissue sarcomas
* Symptomatic or known brain metastasis
* Radiation therapy on the only evaluable lesion
* Anti coagulant treatment
* strong inhibitors or inducers of the isoenzyme CYP3A4 treatment
* Known sero-positivity (HIV, HbC, HbS)or uncontrolled infection
* other prior malignancy except basal cell skin cancer or carcinoma in situ of the cervix
* Clinically significant gastrointestinal abnormalities that may affect the absorption of the IP
* Corrected QT interval \> 480 msec
* Other serious underlying pathology that would preclude study treatment
* Calcium and magnesium levels inferior to standard levels (measured within 14 days before the first pazopanib dose) and potassium levels inferior to standard levels (measured within 72 hours before the first pazopanib dose)