Clinical trial · Interventional
Strength Training and Nutrition Development for African American Youth
USC Center for Transdisciplinary Research on Energetics and Cancer or Obesity-Related Metabolic Disease Risk: Response to Exercise in Minority Youth
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The investigators are conducting an intervention study to examine the effects of a 16-week exercise and diet interventions on prevention of disease, specifically type 2 diabetes and heart disease, in African American youth. Sixty overweight African American boys and girls will be recruited and placed in one of the following intervention groups: 1) Control Group (delayed intervention), 2) Dietary Education Group (nutrition education focused on reducing sugar \& soda, increased fiber \& whole grain intake), or 3) Combination of Strength Training (twice/week for 60 min, progressive increases in exercise volume and intensity) + Dietary Education (nutrition education focused on reducing sugar \& soda, increased fiber \& whole grain intake). The investigators will assess which intervention group has the most effects on health parameters such as weight, body composition, and insulin related measures.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| Cardiovascular Risk | — | UNRESOLVED | — |
| Obesity | — | UNRESOLVED | — |
| Type 2 Diabetes | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Nutrition | Behavioral | — | UNRESOLVED |
| Strength Training & Nutrition | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- NO_INTERVENTION
- label
- Control (C)
- type
- EXPERIMENTAL
- label
- Nutrition (N)
- interventionNames
- Behavioral: Nutrition
- type
- EXPERIMENTAL
- label
- Strength Training & Nutrition (ST)
- interventionNames
- Behavioral: Strength Training & Nutrition
Primary outcomes (1)
- measure
- insulin sensitivity
- timeFrame
- post interventive (week 16)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 14 Years
- Maximum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Overweight (≥85th BMI percentile) * African American: Children will initially be defined as African American if they and both parents and all 4 grandparents self identify as African American. Exclusion Criteria: * Diabetes: Children will not be eligible for participation if they have any diagnostic criteria for diabetes, including polyuria, polydipsia with or without unexplained weight loss, fasting plasma glucose \>126 mg/dl, or a 2-hour plasma glucose \>200 mg/dL during an OGTT using a dose of 1.75g glucose/kg BW (to a maximum of 75g). Children will also be excluded if they test positive for diabetes-related auto-antibodies, including ICA512 and GAD. Children testing positive for type 2 diabetes will be referred for treatment. Children with impaired glucose tolerance (fasting glucose \>100 mg/dL or 2-hour glucose \>140 mg/dl during an oral glucose tolerance test) and/or conditions associated with insulin resistance (e.g. acanthosis nigricans, hypertension, dyslipidemia, poly-cystic ovarian syndrome) will be eligible, as long as they are not receiving treatment and meet other eligibility criteria. * Weight loss or exercise program: currently involved with any weight loss or exercise program, or have been in the 6 months prior to participation * Use of medications: taking any medications known to influence body composition or insulin action/secretion (e.g. prednisone, ritalin, growth hormone) * Syndromes that influence body composition: diagnosed with syndromes or diseases that may influence body composition and fat distribution (e.g. Cushing syndrome, Down syndrome)
References
Publications (1)
- DERIVEDHijazin K, Smith B, Garrett C, Knox A, Kelly LA. Relationship between adiponectin and blood pressure in obese Latino adolescent boys with a family history of type 2 diabetes. BMC Pediatr. 2023 Oct 20;23(1):523. doi: 10.1186/s12887-023-04337-y. PMID 37864156