Clinical trial · Observational
Biomarkers to Distinguish Benign From Malignant Thyroid Neoplasm
Biomarkers in Thyroid Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This protocol will evaluate microRNA biomarkers in blood and fine-needle aspirate biopsies (FNAB) of thyroid nodules. MicroRNA profiles will be determined and evaluated for their utility in pre-operative diagnosis, in particular to distinguish benign from malignant throid neoplasms. Post-surgical fresh-frozen thyroid cancer tissue will be assessed for somatic mutations, mRNA, and microRNA expression patterns. FFPE tissue will be used to obtain H\&E and unstained slides to specific biomarker results using immunohistochemistry.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer of the Thyroid | Malignant Thyroid Gland Neoplasm | CURATED_EXACT | 0.92 |
| Neoplasms, Thyroid | Thyroid Gland Neoplasm | ALIAS | 0.90 |
| Thyroid Adenoma | Thyroid Gland Follicular Adenoma | ALIAS | 0.90 |
| Thyroid Cancer | Malignant Thyroid Gland Neoplasm | CURATED_EXACT | 0.92 |
| Thyroid Carcinoma | Thyroid Gland Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Distinguish follicular adenoma from follicular carcinoma
- timeFrame
- 3 years
- description
- Biomarkers will be identified to distinguish benign follicular adenoma from follicular carcinoma of the thyroid.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 90 Years
Show eligibility criteria text
Inclusion Criteria: * Patient with palpable thyroid nodule suspicious for thyroid neoplasm * Patient selected to undergo fine needle biopsy for cytologic diagnosis * Male (18 years of age or older) * Female (18 years of age or older)
References
Publications (0)
Data not yet available