Clinical trial · Observational
Study of Prevalence of Colorectal Adenoma in 30- to 49-year-old Subjects With a Family History of Colorectal Cancer
Prevalence of Colorectal Adenoma in 30- to 49-year-old Asymptomatic Subjects With a First Relative History of Colorectal Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Current guidelines for initiating screening colonoscopies in patients younger than 50 years of age who have a first relative history of colorectal cancer are controversial. The aim of this study was to prospectively define the prevalence of colorectal adenoma 30- to 49-years-old asymptomatic subjects with a first relative history of colorectal cancer and to compare the data with controls. Design: Single-center prospective study
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Neoplasms | Colorectal Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (1)
- label
- Family history
- description
- 30- to 49-year-old asymptomatic subjects with a first relative history of colorectal cancer
Primary outcomes (1)
- measure
- prevalence of colorectal adenoma(any size)
- timeFrame
- First screening colonoscopy
Secondary outcomes (1)
- measure
- prevalence of advanced adenoma
- timeFrame
- First screening colonoscopy
- description
- 1. Any adenoma ≥10 mm 2. Any villous component 3. High-grade dysplasia
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 30 Years
- Maximum age
- 49 Years
Show eligibility criteria text
Inclusion Criteria: * 30- to 49-year-old asymptomatic subjects * First relative history of colorectal cancer Exclusion Criteria: * previous colonoscopy for any reason * personal history of colorectal adenomas or CRC * history of familial adenomatous polyposis, hereditary nonpolyposis colorectal cancer, or inflammatory bowel disease * documented history of occult GI bleeding, lower gastrointestinal tract bleeding not attributable to hemorrhoid, or * iron deficiency anemia * unexplained weight loss of \>10% of the body weight in the 6 months before colonoscopy * incomplete examination of entire colon
References
Publications (0)
Data not yet available