Clinical trial · Interventional
Pilot Project of Adaptive Thoracic Radiotherapy for Small Cell Lung Cancer
NCT01426841CI-TRIAL-00015756unknownPhase 1ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study is intended to assess the feasibility of adjusting a radiation plan during its course to accommodate for a shrinking tumor target. The investigators hypothesize that an adaptive radiotherapy (RT) planning strategy for small cell lung cancer (SCLC) patients with chest-confined disease will allow for safe delivery of higher doses of chest RT than a non-adaptive RT planning approach without subjecting normal critical structures to unacceptable doses of radiotherapy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Small Cell Lung Cancer | Lung Small Cell Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Adaptive Radiation | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Differences in normal structure/target volume doses achievable using adaptive radiotherapy approach
- timeFrame
- 12-24 months
- description
- Differences in normal structure/target volume doses achievable using adaptive radiotherapy approach will be measured in centigray
Secondary outcomes (2)
- measure
- Local control and patterns of failure
- timeFrame
- 12-24 months
- description
- Local control and patterns of failure
- measure
- Survival
- timeFrame
- 12-24 months
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * patients with histologically or cytologically proven newly diagnosed small cell lung cancer * chest-confined disease (including bulky intrathoracic disease) * adequate pulmonary function tests (FEV-1\>1.0 L, DLCO\>50%) * patients of childbearing potential must practice adequate contraception * Age \> or = 18 years * Karnofsky performance status \> or = 70 * eligible for concurrent chemoradiotherapy Exclusion Criteria: * patients who have undergone complete or subtotal tumour resection * evidence of non-small cell histology * prior or concurrent malignancy except non-melanomatous skin cancer unless disease-free for at least 5 years * prior RT to the thorax or neck * compromised lung function with inadequate pulmonary function tests (FEV-1\<1.0,DLCO\<50%) * pregnant women
References
Publications (0)
Data not yet available
No reference posted for this study.