Clinical trial · Interventional
Evaluation of Microcirculation in Colon Wall and Bowel Anastomosis by Laser Induced Fluorescence Video Angiography
Evaluation of Microcirculation in Colon Wall and Bowel Anastomosis by Laser Induced Fluorescence Video Angiography of Indocyanine Green
NCT01419860CI-TRIAL-00058185completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim of the study is to describe utility of dynamic fluorescence videoangiography of indocyanine green (ICG) in gastrointestinal surgery, for evaluation of microcirculation in colon wall and anastomosis before and after surgical resection; and if this technique can guide the surgeon to peroperative decision making considering recreate a new anastomosis or stoma for preventing anastomotic failure or stomia necrosis.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Benign Colon Diseases | — | UNRESOLVED | — |
| Colon Cancer | Malignant Colon Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Elective colon resection | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Pixel intensity
- description
- Pixel intensity of fluorescence signal describing pixel microcirculation of colon
- interventionNames
- Procedure: Elective colon resection
Primary outcomes (1)
- measure
- Evaluation of microcirculation in colon wall and bowel anastomosis by laser induced fluorescence video angiography of indocyanine green
- timeFrame
- 2 min
- description
- The purpose of our study is to evaluate the microcirculation in the colon wall and bowel anastomosis with laser-induced-fluorescence videoangiography of indocyanine green (ICG), before and after bowel resection.
Secondary outcomes (1)
- measure
- Predicting perfusion deficit with laser-induced ICG fluorescence video angiography
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients with colon cancer requiring elective surgical operation. Exclusion Criteria: * Pregnancy * Children or patients below the age of 18 years * Advanced renal or hepatic failure * Previous allergic reactions to ICG and iodide * Chronic anemia * Active haematologic disease * Women of fertile age needed a negative pregnancy test to be included * Patients with previous colectomy or anorectal surgery were also excluded due to anatomical insult on mesenterial circulation
References
Publications (23)
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- BACKGROUNDMassacesi AL, Sacchi L, Bergamini F, Bottoni F. The prevalence of retinal angiomatous proliferation in age-related macular degeneration with occult choroidal neovascularization. Graefes Arch Clin Exp Ophthalmol. 2008 Jan;246(1):89-92. doi: 10.1007/s00417-007-0638-x. Epub 2007 Jul 25. PMID 17653567
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- BACKGROUNDHolm C, Mayr M, Hofter E, Dornseifer U, Ninkovic M. Assessment of the patency of microvascular anastomoses using microscope-integrated near-infrared angiography: a preliminary study. Microsurgery. 2009;29(7):509-14. doi: 10.1002/micr.20645. PMID 19306390
- BACKGROUNDPena-Tapia PG, Kemmling A, Czabanka M, Vajkoczy P, Schmiedek P. Identification of the optimal cortical target point for extracranial-intracranial bypass surgery in patients with hemodynamic cerebrovascular insufficiency. J Neurosurg. 2008 Apr;108(4):655-61. doi: 10.3171/JNS/2008/108/4/0655. PMID 18377242
- BACKGROUNDMurawa D, Hirche C, Dresel S, Hunerbein M. Sentinel lymph node biopsy in breast cancer guided by indocyanine green fluorescence. Br J Surg. 2009 Nov;96(11):1289-94. doi: 10.1002/bjs.6721.