Clinical trial · Interventional
Assessment of the Effects of Pressors on Graft Blood Flow After Free Tissue Transfer Surgery
An Assessment of the Effects of Pressors on Graft Blood Flow After Free Tissue Transfer Surgery: A Randomised Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Following surgery to remove tumours of the head and neck, patients undergo reconstruction with free flaps - tissue that is taken from elsewhere in the body and given a new blood supply by attaching it to vessels in the neck. Following this type of surgery, patients often need medication to maintain their blood pressure in the intensive care unit. The effect of these drugs on the transplanted tissues is unknown. This study investigates the effects of four commonly used drugs on free flap perfusion.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Free Flap | — | UNRESOLVED | — |
| Head and Neck Cancer | Malignant Head and Neck Neoplasm | ALIAS | 0.90 |
| Hypotension | — | UNRESOLVED | — |
| Oral Cancer | Malignant Lip and Oral Cavity Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Dobutamine | Drug | — | UNRESOLVED |
| Dopexamine | Drug | — | UNRESOLVED |
| Epinephrine | Drug | — | UNRESOLVED |
| Norepinephrine | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Pressors
- description
- Epinephrine, Norepinephrine, Dobutamine, Dopexamine
- interventionNames
- Drug: Epinephrine
- Drug: Norepinephrine
- Drug: Dobutamine
- Drug: Dopexamine
Primary outcomes (1)
- measure
- Absolute change in transfer function (flap vascular resistance) after pressor infusion.
- timeFrame
- Post infusion (at 4 hours)
Secondary outcomes (3)
- measure
- Relative change in transfer function after pressor infusion compared with "normal" tissue.
- timeFrame
- Post infusion (at 4 hours)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 17 Years
Show eligibility criteria text
Inclusion Criteria: * Patients undergoing free tissue transfer surgery at the John Radcliffe Hospital wih planned post-operative admission to the intensive care unit. Exclusion Criteria: * Pregnancy * Weight \>100kg * Contraindications to pressor infusions * Overnight ventilation not indicated
References
Publications (1)
- DERIVEDEley KA, Young JD, Watt-Smith SR. Epinephrine, norepinephrine, dobutamine, and dopexamine effects on free flap skin blood flow. Plast Reconstr Surg. 2012 Sep;130(3):564-570. doi: 10.1097/PRS.0b013e31825dbf73. PMID 22929242