Clinical trial · Interventional
The Use of Self Retaining Sutures in Open and Laparoscopic Partial Nephrectomy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): There was an error made in recruitment therefore patients were not randomized correctly. This was identified in February 2012 and the study was cancelled.
Summary
Brief summary (as posted)
The objective of this study is to assess whether using a different type of suture (barbed sutures) during partial nephrectomy results in fewer postoperative complications than with traditional sutures (non-barbed). The most common complications are urine leakage and bleeding. The investigators believe the barbed suture is less technically difficult to use and will allow the surgeon to better repair the hole left in the kidney after the tumor is removed.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Kidney Neoplasms | Kidney Neoplasm | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| 2-0 absorbable vicryl suture | Device | — | UNRESOLVED |
| Quill knotless tissue-closure device | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Quill knotless tissue-closure device
- description
- During partial nephrectomy participants in this group will receive the Quill Knotless Tissue-Closure device (Angiotech Pharmaceuticals) to close the central defect in their kidney.
- interventionNames
- Device: Quill knotless tissue-closure device
- type
- ACTIVE_COMPARATOR
- label
- 2-0 absorbable vicryl suture
- description
- Participants in this group will be receiving traditional 2-0 vicryl sutures (Ethicon) during partial nephrectomy.
- interventionNames
- Device: 2-0 absorbable vicryl suture
Primary outcomes (2)
- measure
- Postoperative bleeding
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * any person who is being treated for kidney cancer with partial nephrectomy. Exclusion Criteria: * those from whom we cannot obtain adequate informed consent. * those that are converted from partial to radical nephrectomy intraoperatively.
References
Publications (6)
- BACKGROUNDBecker F, Siemer S, Kamradt J, Zwergel U, Stockle M. Important aspects of organ-preserving surgery for renal tumors: indications, new standards, and oncological outcomes. Dtsch Arztebl Int. 2009 Feb;106(8):117-22. doi: 10.3238/arztebl.2009.0117. Epub 2009 Feb 20. PMID 19568369
- BACKGROUNDBecker F, Van Poppel H, Hakenberg OW, Stief C, Gill I, Guazzoni G, Montorsi F, Russo P, Stockle M. Assessing the impact of ischaemia time during partial nephrectomy. Eur Urol. 2009 Oct;56(4):625-34. doi: 10.1016/j.eururo.2009.07.016. Epub 2009 Jul 28. PMID 19656615
- BACKGROUNDGill IS, Kavoussi LR, Lane BR, Blute ML, Babineau D, Colombo JR Jr, Frank I, Permpongkosol S, Weight CJ, Kaouk JH, Kattan MW, Novick AC. Comparison of 1,800 laparoscopic and open partial nephrectomies for single renal tumors. J Urol. 2007 Jul;178(1):41-6. doi: 10.1016/j.juro.2007.03.038. Epub 2007 May 11. PMID 17574056
- BACKGROUNDNguyen MM, Gill IS. Halving ischemia time during laparoscopic partial nephrectomy. J Urol. 2008 Feb;179(2):627-32; discussion 632. doi: 10.1016/j.juro.2007.09.086. Epub 2007 Dec 21. PMID 18082215
- BACKGROUNDTurna B, Frota R, Kamoi K, Lin YC, Aron M, Desai MM, Kaouk JH, Gill IS. Risk factor analysis of postoperative complications in laparoscopic partial nephrectomy. J Urol. 2008 Apr;179(4):1289-94; discussion 1294-5. doi: 10.1016/j.juro.2007.11.070. Epub 2008 Mar 4. PMID 18289584
- BACKGROUNDEl-Ghazaly, T.H. and Rendon, R.A. 2011. Perioperative outcomes of laparoscopic partial nephrectomy using self-retaining sutures (SRS) and early clamp removal versus conventional kidney and collecting system repair. Canadian Urological Association Journal 5(3 suppl 1) s3-s114 sub-article 66