Clinical trial · Interventional
Control of Emergence Blood Pressure During Craniotomy for Tumor Surgery Between Labetolol and Diltiazem
A Comparative Study in the Control of Emergence Blood Pressure During Craniotomy for Tumor Surgery Between Labetolol (Avexa) and Diltiazem
NCT01408524CI-TRIAL-00014147completedPhase 1 / Phase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to determine the effectiveness of the antihypertensive drugs in the control of emergence blood pressure after tumor resection craniotomy; compared between labetalol (Avexa) and diltiazem (Herbessor). Also the investigators seek to determine the effective dose of the antihypertensive drugs and their side effects in Thai population.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Craniotomy | — | UNRESOLVED | — |
| Hypertension | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Diltiazem | Drug | — | UNRESOLVED |
| Labetalol | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Diltiazem
- description
- 2.5 mg iv q 2-5 min for keeping SBP below 140 mmHg during the emergence
- interventionNames
- Drug: Diltiazem
- type
- ACTIVE_COMPARATOR
- label
- Labetalol
- description
- 2.5 mg iv q 2-5 min for keeping SBP below 140 mmHg during the emergence
- interventionNames
- Drug: Labetalol
Primary outcomes (1)
- measure
- The number of the patients who have systolic blood pressure below 140 mmHg
- timeFrame
- 3 hours
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * patients who scheduled for craniotomy for tomor removal Exclusion Criteria: * allergic to labetalol or diltiazem * Bradycardia \< 60 beat/min * Second or third degree heart block * Severe asthma or severe COPD * Brain stem tumor
References
Publications (0)
Data not yet available
No reference posted for this study.