Clinical trial · Interventional
Beta-Tricalcium Phosphate Bone Graft in Treating Patients Undergoing Surgery For Metastatic Spine Cancer
ChronOS Stability Study: For Metastatic Cancer
NCT01407341CI-TRIAL-00013686terminatedPhase 1ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Lack of funding
Summary
Brief summary (as posted)
This pilot clinical trial studies beta-tricalcium phosphate bone graft in treating patients undergoing surgery for metastatic spine cancer. A bone graft may help healing and bone growth in patients undergoing surgery for spine cancer
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Adult Spinal Cord Neoplasm | Adult Spinal Cord Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Spinal Bone Metastases | — | UNRESOLVED | — |
| Spinal Cord Compression | — | UNRESOLVED | — |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| bone graft | Procedure | — | UNRESOLVED |
| musculoskeletal complications management/prevention | Procedure | — | UNRESOLVED |
| quality-of-life assessment | Procedure | — | UNRESOLVED |
| questionnaire administration | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Supportive care (ChronOS)
- description
- Patients undergo placement of beta-tricalcium phosphate bone graft strips posterolaterally during surgery.
- interventionNames
- Procedure: musculoskeletal complications management/prevention
- Procedure: bone graft
- Procedure: quality-of-life assessment
- Other: questionnaire administration
Primary outcomes (1)
- measure
- Achievement of durable posterolateral fusion
- timeFrame
- Within 12 months
- description
- Measured from x-ray and/or computed tomography (CT) scans. Standard criteria of determining fusion is visualization of continuous trabeculating bone bridging the transverse processes and facets on AP and lateral x-rays or when there is \< 2 degree angular motion and \< 2mm of translation on standing flexion and extension radiographs.
Secondary outcomes (5)
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * All patients undergoing surgery for spinal decompression for tatic spine cancer who require bone substitute for a posterolateral spinal fusion * Patients may or may not have posterolateral instrumentation Exclusion Criteria: * Status-post previous fusion with allogeneic bone graft
References
Publications (0)
Data not yet available
No reference posted for this study.