Clinical trial · Interventional
Comparative Study of Intraoperative MRI-guided vs. Conventional Glioma Surgery
Resection Control of Primary Brain Tumours Using a Low-Field Intraoperative MRI
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Excision to the maximum possible extent marks the first step of glioma surgery. Depending on tumour histology, adjuvant treatment consists of radio- and/or chemotherapy. Multi-centre studies have shown that the presence of residual tumour according to MRI-criteria is a prognostic factor in this incurable condition. In order to improve the extent of resection, several methods, in particular intraoperative imaging techniques, have become available to demonstrate already during surgery whether the goal of surgery has been achieved. The intraoperative MRI devices currently available differ in their magnetic field strengths and image resolution, but also in their amount of interference with the surgical workflow. Prospective, high-class evidence data to promote the use of intraoperative MRI in glioma surgery are lacking. To assess whether the rate of radiologically complete tumour resections can be improved by using intraoperative MRI-guidance, we designed this prospective, randomized trial. We hypothesized that the extent of resection that can be achieved using an intraoperative MRI is greater than that of conventional microsurgical tumor resection.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Glioma | Glioma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| intraoperative MRI-guided tumor resection | Procedure | — | UNRESOLVED |
| standard microsurgery | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- intraoperative MRI
- description
- tumor resection with intraoperative MRI-guidance
- interventionNames
- Procedure: intraoperative MRI-guided tumor resection
- type
- ACTIVE_COMPARATOR
- label
- conventional group
- description
- standard microsurgical tumor resection
- interventionNames
- Procedure: standard microsurgery
Primary outcomes (1)
- measure
- Extent of Resection
- timeFrame
- 72 hours
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * known or suspected contrast-enhancing glioma (primary and recurrent) * location of the tumor permits intended gross-total resection Exclusion Criteria: * tumor location prohibits or questions gross-total resection * contraindications to undergo MRI examinations
References
Publications (1)
- RESULTSenft C, Bink A, Franz K, Vatter H, Gasser T, Seifert V. Intraoperative MRI guidance and extent of resection in glioma surgery: a randomised, controlled trial. Lancet Oncol. 2011 Oct;12(11):997-1003. doi: 10.1016/S1470-2045(11)70196-6. Epub 2011 Aug 23. PMID 21868284