Clinical trial · Observational
Phase II Evaluation of Exhaled Nitric Oxide (NO)
Phase II Evaluation of Exhaled Nitric Oxide as a Predictive Biomarker for Radiation Pneumonitis
NCT01392144CI-TRIAL-00009880completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this clinical research study is to learn if the level of nitric oxide you breathe out may relate to the amount of breathing complications that you may experience due to radiation treatment.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Nitric oxide breath test | Procedure | — | UNRESOLVED |
| Questionnaires | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Nitric Oxide Breath Analysis
- description
- Nitric Oxide Breath Test + Questionnaires
- interventionNames
- Procedure: Nitric oxide breath test
- Behavioral: Questionnaires
Primary outcomes (1)
- measure
- Ratio Between Weekly and Baseline Nitric Oxide (NO) Measurements
- timeFrame
- Weekly starting prior to start of radiation therapy to follow-up visits for 6 months.
- description
- Ratio between weekly and baseline nitric oxide measurements in participants receiving thoracic radiation therapy. Exhaled nitric oxide measured in triplicate on a weekly basis during radiotherapy and on each follow-up visit.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Patients will sign consent for the study. 2. Patients with pathologic diagnosis of esophagus or lung cancer. 3. Patient plans to receive radiation treatment at MD Anderson. 4. Patient will receive \>/= 5 weeks of thoracic radiotherapy. 5. Patients \>/= 18 years of age. Exclusion Criteria: 1. Patients who have asthma. 2. Women of childbearing potential (A woman of child-bearing potential is a sexually mature woman who has not undergone a hysterectomy or who has not been naturally postmenopausal for at least 24 consecutive months \[i.e., who has had menses at any time in the preceding 24 consecutive months\]) must practice effective contraception (oral, injectable, or implantable hormonal contraceptive; tubal ligation; intra-uterine device; barrier contraceptive with spermicide) throughout the study.
References
Publications (0)
Data not yet available
No reference posted for this study.