Evaluation of 11 C-Choline PET-CT for Detection of Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC)is the most frequent primitive tumour of the liver. Recently, several research studies reported that 11C-choline PET has shown a high detection rate of well differentiated HCC, which is an early stage of primary liver cancer. The aim of this study was to prospectively evaluate the diagnostic accuracy of 11C-choline PET-CT to detect HCC in cirrhotic or non cirrhotic patients.

Sex

All

Minimum age

18 Years

Inclusion Criteria:

* Patients up to 18 years old with
* Patients with suspicion hepatocellular carcinoma on conventional imaging(hepatic ultrasonography, abdominal computed tomography, dynamic resonance magnetic)and/or on alpha fetoprotein measurement
* Patients with suspicion recurrence of hepatocellular carcinoma on conventional imaging(hepatic ultrasonography, abdominal computed tomography, dynamic resonance magnetic)and/or on alpha fetoprotein measurement
* Patients which perform two conventional imaging techniques, consisting in dynamic magnetic resonance imaging (MRI) and computed tomography (CT)and must have an alpha fetoprotein measurement
* Patients which perform 18F-FDG PET-CT
* Informed Consent Form signed and dated by patients
* Patients which are "Security Social" affiliated

Exclusion Criteria:

* Pregnant or suckling women
* Women able to procreate, without efficient birth control
* Patients with an other tumoral disease
* Patients with chemotherapy or surgery from less than four weeks
* Patients with radiotherapy from less four months

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