Clinical trial · Observational
Biomarkers in Predicting Response to Chemotherapy in Samples From Young Patients With Osteosarcoma
Observational - Methylation Status as Predictor of Response to Neoadjuvant Chemotherapy in Osteosarcoma
NCT01374672CI-TRIAL-00017886completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This research study is studying biomarkers in predicting response to chemotherapy in samples from young patients with osteosarcoma. Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict how patients will respond to treatment.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Localized Osteosarcoma | Osteosarcoma | CURATED_BROADER | 0.78 |
| Metastatic Osteosarcoma | Osteosarcoma | CURATED_BROADER | 0.78 |
| Osteoblastic Osteosarcoma | Osteoblastic Osteosarcoma | ONTOLOGY_EXACT | 0.98 |
| Recurrent Osteosarcoma | Osteosarcoma | CURATED_BROADER | 0.78 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| laboratory biomarker analysis | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Correlative studies
- description
- DNA and RNA extracted from biopsy samples are analyzed for methylation changes and transcription changes by ligation-mediated PCR and mass-array genotyping.
- interventionNames
- Other: laboratory biomarker analysis
Primary outcomes (1)
- measure
- Methylated status as predictor of response to neoadjuvant chemotherapy
- timeFrame
- Baseline
- description
- Performed on a locus-by-locus basis using Poisson regression (for count data) and/or two-group t-tests, with correction (Satterwaithe's) for unequal within-group variances.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 10 Years
- Maximum age
- 20 Years
Show eligibility criteria text
Inclusion Criteria: * Diagnosed with high-grade osteoblastic osteosarcoma * Biopsy samples from patients who had good or poor response to neoadjuvant chemotherapy available * All specimens should be from post-menarchal females or age-matched males with appendicular tumors * Patients' clinical data including chemotherapy received, event-free survival, and overall survival available * See Disease Characteristics
References
Publications (0)
Data not yet available
No reference posted for this study.