Clinical trial · Interventional
Effects of Anesthetic Technique on Immune and Inflammatory Systems Following Radical Prostatectomy
Comparison Between Epidural and Patient Controlled Analgesia on Immunological and Inflammatory Systems Following Radical Retropubic Prostatectomy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Several recently published retrospective studies show that regional anaesthesia (RA) can reduce cancer-related mortality following surgical treatment of colorectal, breast and prostate cancers and malignant melanoma. If these results are true, then the choice of perioperative pain management is as beneficial, or even better, than the current oncological therapies. This theory needs to be investigated in a prospective, randomized and controlled trail. We shall perform a prospective, randomized study comparing the effects of Thoracic epidural analgesia (TEA) or patient controlled analgesia (PCA) on postoperative immunological and inflammatory markers in order to understand whether the protective effects, if any, of regional analgesia are due to changes in these markers or whether the underlying mechanisms is not mediated via this stress signalling pathway.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Prostate Cancer | Malignant Prostate Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Patient controlled analgesia (PCA) | Drug | — | UNRESOLVED |
| Thoracic Epidural Analgesia (TEA) | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Thoracic Epidural Analgesia (TEA)
- description
- TEA is used for perioperative pain management, having been used both intra- and postoperatively, up to 48 h.
- interventionNames
- Drug: Thoracic Epidural Analgesia (TEA)
- type
- ACTIVE_COMPARATOR
- label
- Patient controlled analgesia (PCA)
- description
- PCA is the standard of pain management and is usually used for up to 48 h postoperative for pain management following radical prostatectomy.
- interventionNames
- Drug: Patient controlled analgesia (PCA)
Primary outcomes (1)
- measure
- Natural Killer Cell activity
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 50 Years
- Maximum age
- 78 Years
Show eligibility criteria text
Inclusion Criteria: * ASA physical status 1-2 * Radical retropubic prostatectomy Exclusion Criteria: * Chronic use of opiates * Contraindication to epidural analgesia * Allergy to component drugs * Chronic inflammatory diseases * Use of steroids perioperatively
References
Publications (0)
Data not yet available