e- Ab Sensor-based Real-time Detection of Mutant EGFR in Clinical Specimens From Patients of Non-small Cell Lung Cancer

The purpose of this study is to develop a real-time diagnostic technique with e- Ab sensor for specific EGFR mutation detection in clinical specimens of NSCLC patients, the investigators conduct a prospective clinical study. In comparison with results from direct sequencing of EGFR, the investigators evaluate the performance of e- Ab sensor, including reproducibility, sensitivity, specificity, and cross-reaction (such as detection of EGFR mutations other than L858R and DelL746-A750). The potential factors which may interfere with the results would be investigated. With such technique, the investigators can obtain EGFR mutation information of NSCLC patients in cost-saving and time-saving way and can offer more individualized treatment for the investigators patients.

Sex

All

Minimum age

18 Years

Inclusion Criteria:

Inclusion: Patients will be enrolled if they fulfill all of the following criteria

1. With indication for the following interventions:

   Thoracentesis Fine-needle aspiration and biopsy of primary tumor or metastases Bronchoalveolar lavage
2. With enough residual specimens for further study (Patients would be excluded if they have only limited amount of clinical specimens, which should all be sent for clinical analysis.)
3. Consent is obtained from the patient

Exclusion Criteria:

* Patients will be excluded if they couldn't sign the consent. Otherwise, no specific exclusion criteria were considered.