Clinical trial · Interventional
PET With [18F]HX4 in Head and Neck Cancer
Non Invasive Imaging of [18F]HX4 With Positron-Emission-Tomography (PET) in Head and Neck Cancer.
NCT01347281CI-TRIAL-00025680completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim of this study is to (i) Determine if tumor hypoxia can be accurately visualised with \[18F\] HX4 PET imaging in head and neck tumors (ii) correlate the \[18F\] HX4 PET images with blood and tissue markers and (iii) investigate the quality and optimal timing of \[18F\] HX4 PET imaging (iv) compare \[18F\] HX4 PET uptake with \[18F\] FDG PET uptake before and after treatment.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer of the Head and Neck | Malignant Head and Neck Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Injection of [18F]HX4 | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- [18F]HX4 PET
- description
- Injection of \[18F\]HX4
- interventionNames
- Procedure: Injection of [18F]HX4
Primary outcomes (1)
- measure
- Visualisation of tumor hypoxia with [18F] HX4 PET imaging
- timeFrame
- 2 years
- description
- Visualisation of tumor hypoxia with \[18F\] HX4 PET imaging
Secondary outcomes (8)
- measure
- Observe spatial and temporal stability of [18F] HX4 PET images
- timeFrame
- 2 years
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 100 Years
Show eligibility criteria text
Inclusion Criteria: * Histological or cytological confirmed HNSSC of the oral cavity, oropharynx, hypopharynx, larynx, T2-T3-T4, any N, M0 * Tumor diameter ≥ 2,5 cm * WHO performance status 0 to 2 * Scheduled for primary curative (concurrent chemo-) radiotherapy * No previous surgery to the head and neck * No previous radiation to the head and neck * Adequate renal function (calculated creatinine clearance at least 60 ml/min). * The patient is willing and capable to comply with study procedures * 18 years or older * Have given written informed consent before patient registration Exclusion Criteria: * No recent (\< 3 months) myocardial infarction * No Uncontrolled infectious disease * Not pregnant or breast feeding and willing to take adequate contraceptive measures during the study
References
Publications (0)
Data not yet available
No reference posted for this study.