Clinical trial · Observational
Cruciferous Vegetable Intake and Histone Status in Screening Colonoscopy Patients
NCT01344330CI-TRIAL-00048957completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This research study will assess cruciferous vegetable intake in patients presenting for screening colonoscopy and correlate intake with histone status and histone deacetylace (HDAC) expression in tissue biopsy specimens and peripheral blood mononuclear cells (PBMCs). The investigators will also measure sulforaphane (SFN) metabolites in blood as a biomarker of cruciferous vegetable intake.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colon Cancer | Malignant Colon Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (1)
- label
- Screening colonoscopy patients
- description
- Men and women age 50 to 75 scheduled for screening colonoscopy
Primary outcomes (1)
- measure
- Cruciferous vegetable intake correlated with SFN and I3C urinary metabolites
- timeFrame
- At colonoscopy (day 1)
Secondary outcomes (3)
- measure
- Cruciferous vegetable intake and p21 expression (qRT-PCR, ChIP in PBMCs)
- timeFrame
- at colonoscopy
- measure
- Cruciferous vegetable intake correlated with acetylated histone expression (PBMCs, colon tissue),
- timeFrame
- at colonoscopy
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 50 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion criteria: * scheduled for screening colonoscopy * off NSAID or aspirin therapy in accordance with OHSU endoscopy clinic guidelines * INR 0.90-1.20 * hemoglobin ≥ 13.5 (men) or 12.0 (women) * platelets ≥100,000/μL * Chem screen results within normal limits * negative (serum or urine) pregnancy test done ≤7 days prior to colonoscopy for women of childbearing potential only * ASA performance status \<2 Exclusion criteria: * history of colon cancer or adenomatous polyps * current smoker * medical history of chronic obstructive pulmonary disease * current oral steroid therapy * current therapy with valproate or other pharmacological drugs associated with HDAC inhibition * use of oral antibiotics within 3 months prior to entry into study * significant active medical illness which in the opinion of the investigator would preclude collection/interpretation of colon tissue * diagnosis of hemophilia, van Willebrand's disease or other bleeding disorder * use of warfarin or other blood thinning agents * inflammatory bowel disease.
References
Publications (0)
Data not yet available
No reference posted for this study.