Clinical trial · Interventional
Palliative Radiotherapy for Symptomatic Locally Advanced Gastric Cancer: A Phase II Trial
NCT01341756CI-TRIAL-00004781unknownPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The hypothesis of this study is that a radiotherapy dose of 36Gy in 12 fractions, which equates to a BED of 48.6Gy, increases the response rates of symptom relief compared to historical controls.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gastric Cancer | Malignant Gastric Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Palliative Radiotherapy | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Radiotherapy for gastric cancer
- description
- Single arm study
- interventionNames
- Radiation: Palliative Radiotherapy
Primary outcomes (1)
- measure
- Response of bleeding to radiotherapy
- timeFrame
- At the 12th fraction of radiotherapy and at one month post radiotherapy
- description
- Percentage of patients who do not require blood transfusion after radiotherapy
Secondary outcomes (1)
- measure
- Number of patients who develop anorexia, nausea, vomiting as per common toxicity criteria v3.0
- timeFrame
- within the first 14 days from start of radiotherapy
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 21 Years
Show eligibility criteria text
Inclusion Criteria: * Biopsy proven adenocarcinoma of the stomach * Treated with palliative intent * At least one index symptom such as bleeding, obstruction or pain * No prior abdominal radiotherapy * Not on chemotherapy Exclusion Criteria: * Patients treated with radical intent * Previous abdominal radiotherapy * Patients on chemotherapy
References
Publications (1)
- DERIVEDTey J, Zheng H, Soon YY, Leong CN, Koh WY, Lim K, So JBY, Shabbir A, Tham IWK, Lu J. Palliative radiotherapy in symptomatic locally advanced gastric cancer: A phase II trial. Cancer Med. 2019 Apr;8(4):1447-1458. doi: 10.1002/cam4.2021. Epub 2019 Feb 20. PMID 30790469