Clinical trial · Interventional
Fast-track Perioperative Program for Laparoscopic Colorectal Surgery
The Impact of Fast-track Perioperative Program on the Clinical and Immunological Outcomes After Laparoscopic Colorectal Surgery in Hong Kong Chinese Patients: A Prospective Randomized Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Background: Laparoscopic colorectal surgery has been shown by randomized trials to be associated with better short-term clinical outcomes when compared with open surgery. However, in a traditional perioperative care setting, the reduction in hospital stay following laparoscopic surgery in these trials was modest. Fast-track perioperative programs have been introduced in the West to optimize perioperative factors to reduce the physiological/psychological stress of open colorectal surgery. However, few studies have evaluated the impact of fast-track programs on the outcomes after laparoscopic colorectal surgery. Objective: To compare the clinical and immunological outcomes of Hong Kong Chinese patients undergoing laparoscopic surgery for colorectal cancer with a "traditional" vs. a "fast-track" perioperative program. Design: Prospective randomized trial. Subjects: One hundred and twenty-eight consecutive patients undergoing elective laparoscopic resection of non-metastatic colonic and upper rectal cancer will be recruited. Interventions: Patients will be randomized to a "traditional" or a "fast-track" perioperative program. Outcome measures: Primary outcome: total postoperative hospital stay, including hospital stay of patients who are readmitted within 30 days after surgery. Secondary outcomes: immunological parameters (including systemic cytokine response and cell-mediated immune function), morbidity and mortality, quality of life, and medical costs.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Fast-track perioperative program | Other | — | UNRESOLVED |
| Traditional perioperative program | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Fast-track perioperative program
- interventionNames
- Other: Fast-track perioperative program
- type
- ACTIVE_COMPARATOR
- label
- Traditional perioperative program
- interventionNames
- Other: Traditional perioperative program
Primary outcomes (1)
- measure
- Duration of hospital stay
- timeFrame
- Up to 1 month
- description
- Total postoperative hospital stay, including hospital stay of patients who are readmitted within 30 days after surgery.
Secondary outcomes (7)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion criteria: * Consecutive patients undergoing elective laparoscopic resection of colonic and upper rectal cancer, * Age of patients between 18 and 75 years * Patients with American Society of Anesthesiologists grading I-II * Patients with no severe physical disability * Patients who require no assistance with the activities of daily living * Informed consent available Exclusion criteria: * Patients undergoing laparoscopic low anterior resection with total mesorectal excision, abdominoperineal resection, or total/proctocolectomy * Patients with planned stoma creation * Patients undergoing emergency surgery * Patients with known metastatic disease * Patients with previous history of abdominal surgery * Patients with known immunological dysfunction * Patients who are taking steroids or immunosuppressive agents * Patients with chronic pain syndrome
References
Publications (0)
Data not yet available