Clinical trial · Observational
Biomarkers in Tissue Samples From Young Patients With Liver Cancer
Genetics and Biology of Liver Tumorigenesis in Children
NCT01336881CI-TRIAL-00022247completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This research trial is studying biomarkers in tissue samples from young patients with liver cancer. Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Childhood Hepatoblastoma | Childhood Hepatoblastoma | ONTOLOGY_EXACT | 0.98 |
| Stage I Childhood Liver Cancer | Childhood Malignant Liver Neoplasm | CURATED_BROADER | 0.78 |
| Stage II Childhood Liver Cancer | Childhood Malignant Liver Neoplasm | CURATED_BROADER | 0.78 |
| Stage III Childhood Liver Cancer | Childhood Malignant Liver Neoplasm | CURATED_BROADER | 0.78 |
| Stage IV Childhood Liver Cancer | Childhood Malignant Liver Neoplasm | CURATED_BROADER | 0.78 |
Interventions
Interventions (5)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| diagnostic laboratory biomarker analysis | Other | — | UNRESOLVED |
| gene expression analysis | Genetic | — | UNRESOLVED |
| microarray analysis | Genetic | — | UNRESOLVED |
| nucleic acid sequencing | Genetic | — | UNRESOLVED |
| RNA analysis | Genetic | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Correlative (tissue analysis)
- description
- Archived tumor tissue samples are analyzed for hepatoblastoma and other liver tumor biomarkers by microRNA array profiling and exome sequencing. Results are then compared with patients' clinical data.
- interventionNames
- Genetic: RNA analysis
- Genetic: gene expression analysis
- Genetic: microarray analysis
- Genetic: nucleic acid sequencing
- Other: diagnostic laboratory biomarker analysis
Primary outcomes (1)
- measure
- Biomarkers associated with hepatoblastoma subtypes and cancer stages
- timeFrame
- Baseline
Secondary outcomes (2)
- measure
- Genes involved in embryonic development and/or stem cell signaling pathways for which preliminary data suggests involvement in the pathogenesis of hepatoblastoma
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Maximum age
- 16 Years
Show eligibility criteria text
Inclusion Criteria: * Diagnosis of hepatoblastoma or other liver cancer including the following subtypes: * Pure fetal histology * Transitional histology * Small cell undifferentiated histology * Participated on the Children's Oncology Group (COG) clinical trials * Available data and tumor samples
References
Publications (0)
Data not yet available
No reference posted for this study.