GDC-0980 in Combination With a Fluoropyrimidine, Oxaliplatin, and Bevacizumab in Patients With Advanced Solid Tumors

Inclusion Criteria:

* Histologically or cytologically documented locally advanced or metastatic solid tumors for which established therapy is ineffective, not tolerable, or does not exist
* Patients with histologically or cytologically documented locally advanced or metastatic breast cancer who have received at least one prior chemotherapy-based regimen for incurable disease (Arm A)
* Patients with histologically or cytologically documented locally advanced or metastatic CRC who have not received prior oxaliplatin-based therapy within 1 year of initiation of study treatment. (Arm B)

Exclusion Criteria:

* Prior anti-cancer therapy that fulfills the following criteria: a total of more than six courses of an alkylating agent, a total of more than four courses of carboplatin-containing chemotherapy regimens, and a total of more than two courses of nitrosoureas or mitomycin C, high-dose chemotherapy requiring stem-cell support, and irradiation to \>= 25% of bone marrow-bearing areas
* Current dyspnea at rest because of complications of advanced malignancy or other disease requiring continuous oxygen therapy
* Known deficiency of dihydropyrimidine dehydrogenase (DPD)
* Bisphosphonate therapy for symptomatic hypercalcemia
* Known untreated or active central nervous system (CNS) metastases
* Pregnancy, lactation, or breastfeeding

For Arm B:

* Inadequately controlled hypertension
* Prior history of hypertensive crisis or hypertensive encephalopathy
* History of myocardial infarction or unstable angina within 6 months prior to the first dose of study treatment
* History of stroke or transient ischemic attacks within 6 months prior to the first dose of study treatment
* Significant vascular disease within 6 months prior to the first dose of study treatment
* History of hemoptysis within 1 month prior to the first dose of study treatment
* Patients with one or more pulmonary tumor masses with evidence of cavitation
* Evidence of bleeding diathesis or significant coagulopathy
* Core biopsy or other minor surgical procedure, excluding placement of a vascular access device, within 7 days prior to the first dose of study treatment
* History of abdominal fistula, GI perforation, or intra-abdominal abscess within 6 months prior to the first dose of study treatment
* Clinical signs or symptoms of GI obstruction or requirement for parenteral hydration, parenteral nutrition, or tube feeding
* Evidence of abdominal free air not explained by paracentesis or recent surgical procedure
* Serious, non-healing wound, active ulcer, or untreated bone fracture
* The presence of an ulcerating breast cancer tumor will not render a patient ineligible
* Proteinuria