Clinical trial · Interventional
Comparative Study of Lubiprostone and PEG Preparation Versus Conventional PEG Preparation for Colonoscopy
Comparative Study of Lubiprostone and PEG Preparation Versus Conventional PEG Preparation to Enhance the Colonoscopy Preparation Quality in an Indian Tertiary Care Center.
NCT01324284CI-TRIAL-00009899LubiprostonecompletedPhase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Lubiprostone as an adjunct to the standard bowel preparation regime the quality of bowel preparation can be improved for a good colonoscopic examination without missing lesions and complications.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Carcinoma | Colorectal Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Lubiprostone | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Lubiprostone
- description
- Lubiprostone with PEG solution versus Placebo with PEG solution
- interventionNames
- Drug: Lubiprostone
- type
- PLACEBO_COMPARATOR
- label
- lubiprostone versus placebo
Primary outcomes (1)
- measure
- Quality of bowel preparation in Same day Low volume PEG with placebo versus same day low volume PEG with Lubiprostone
- timeFrame
- 2 months
- description
- Quality of bowel preparation is based on Boston Bowel Preparation Score (BBPS)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: 1. All adult patient referred for colonoscopy to AIG 2. Age 18 - 75 years old Exclusion Criteria: 1. Acute GI bleeding. 2. Patient of bowel preparation regime other than excepted for the study. 3. Renal insufficiency. 4. Dementia. 5. Symptomatic heart failure. 6. Recent Myocardial Infarction. 7. Patients with ileus. 8. Suspected bowel obstruction. 9. Prior alimentary tract surgery. 10. Significant gastroparesis. 11. Gastric outlet obstruction. 12. Toxic colitis or megacolon. 13. Pregnant or lactating patients.
References
Publications (1)
- DERIVEDBanerjee R, Chaudhari H, Shah N, Saravanan A, Tandan M, Reddy DN. Addition of Lubiprostone to polyethylene glycol(PEG) enhances the quality & efficacy of colonoscopy preparation: a randomized, double-blind, placebo controlled trial. BMC Gastroenterol. 2016 Oct 13;16(1):133. doi: 10.1186/s12876-016-0542-0. PMID 27737636