Effect of EPA on Aerobic Performance, Muscle, and Quality of Life in Colorectal Cancer Surgery Patients

Inclusion Criteria:

* Colorectal cancer patients listed for open curative tumour resection by means of: Right Hemi Colectomy, Left Hemi-colectomy or Anterior Resection, not having neo-adjuvant chemotherapy.
* Aged 18 - 85 years old.

Exclusion Criteria:

* Strenuous exercise 48 hours before the preoperative assessment.
* Intramuscular injections within 48 hours of any study day.
* Known peripheral neuropathy or myopathy.
* Patients with mobility problems, wheelchair bound or have suffered a previous cerebro-vascular accident with residual impairment of mobility.
* Patients with major/ minor trauma (Motor vehicle accidents or ground falls, firearm injury, drowning, struck by and against injuries).
* Pregnant women. Pregnancy test will be done at the beginning of the study day.
* Patients without mental capacity to give signed consent.
* Patients already taking fish-oil derived nutritional supplement.
* Patients with impaired oral intake.
* Patients known to have metastatic disease.
* Patients having neoadjuvant chemotherapy prior to resection, which may confound results.
* Patients having laparoscopic procedures.
* Patients identified having cardiorespiratory comorbidity considered unsuitable for surgery: unstable angina, myocardial infarction within last 3 months, severe aortic stenosis, pulmonary hypertension, HOCM, acute myopericarditis, chronic heart failure New York Heart Association class 3 and above and impaired left ventricular ejection fraction (less than 43%). Respiratory contraindications include severe COPD, emphysema, fibrosing alveolitis, Interstitial lung disease and FEV1 less than 1.5.