Clinical trial · Observational
Comparison of Creatinine Clearance Calculation for Estimation of GFR in Patients Receiving HD Methotrexate
Comparison of Creatinine Clearance Calculation Methods for Estimation of Glomerular Filtration Rate in Patients Receiving High-Dose Methotrexate
NCT01319591CI-TRIAL-00036670completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to compare different estimates of calculating creatinine clearance by mathematical formula and compare them to creatinine clearance based on a timed urine collection in patients who received high-dose methotrexate for the treatment of primary CNS lymphoma or CNS involvement of systemic lymphoma.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| CNS Involvement of Systemic Lymphoma | — | UNRESOLVED | — |
| CNS Lymphoma | Central Nervous System Lymphoma | ALIAS | 0.90 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (1)
- label
- CNS lymphoma patients
Primary outcomes (1)
- measure
- To identify a serum creatinine-based equation that gives the best estimate of CrCl as compared to a measured creatinine clearance formula.
- timeFrame
- 1 year
- description
- Serum creatinine-based equations to be included in that analysis are: Cockcroft-Gault with the following weight descriptors; ideal body weight, actual body weight, and adjusted body weight; Modified MDRD; CKD-EPI.
Secondary outcomes (1)
- measure
- To further compare each formula in a different subset of patients.
- timeFrame
- 1 year
- description
- To further compare each formula in a different subset of patients: Age \< 65 years and \>/= 65 years; body mass index \< 25, 25-30, 30-35, and \> 35; serum creatinine \<1.5 mg/dL and \>/= 1.5 mg/dL.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age \>/= 18 years * Received high-dose methotrexate therapy at Dana-Farber Cancer Institute/Brigham and Women's Hospital for the treatment of primary CNS lymphoma or CNS involvement of systemic lymphoma * Available timed urine collection within 1 week of HDMTX Exclusion Criteria: * Receiving high-dose methotrexate for indications other than primary CNS lymphoma or CNS involvement of systemic lymphoma * Documented viral hepatitis
References
Publications (0)
Data not yet available
No reference posted for this study.