Clinical trial · Interventional
Paracetamol for Cancer Pain
Optimizing Medication for Cancer Pain. The Effect of Paracetamol. A Clinical and Pharmacological Trial to Research Whether Paracetamol Gives an Additional Effect on Pain Relief When the Patient is Treated With High Doses of Opioids
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Randomised, double-blind placebo controlled cross-over trial Main goal: Optimize the medical pain treatment for patients with advanced cancer disease Study goal: Measure paracetamol's additional analgesic effect in a situation where the patient is concomitantly treated with oral opioids eqv. morphine \> 100 mg/d.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Advanced Cancer | Malignant Neoplasm | CURATED_BROADER | 0.78 |
| Opioid Use, Unspecified | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| paracetamol | Drug | — | UNRESOLVED |
| placebo tablets | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- PLACEBO_COMPARATOR
- label
- Placebo pills
- description
- Placebo tablets resembling paracetamol 500 mg are given as alternative 2 tablets 4 times daily
- interventionNames
- Drug: placebo tablets
- type
- ACTIVE_COMPARATOR
- label
- oral paracetamol 4 g daily
- description
- Patients are given 2 tablets of 500 mg paracetamol on a regular basis 4 times daily
- interventionNames
- Drug: paracetamol
Primary outcomes (1)
- measure
- Pain reduction caused by paracetamol 4g/d
- timeFrame
- Last day in each 3 days study period
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Adults (\> 18 years) of both sexes * Diagnosed with advanced cancer disease * Ongoing medicinal pain relief treatment in stable dosing with oral opiates equivalent to \> 100 mg oral morphine daily * NRS median pain score last 24 hrs \> 4 * Able to take tablets (paracetamol) orally Exclusion Criteria: * Mental or physical deficiency precluding data collection. * Reduced liver function judged with bilirubin, INR and transaminases * Anticoagulation with warfarin * Ongoing use of NSAIDs or 5-HT3 antagonists, or use of such drugs last week * Ongoing palliative radiation treatment or radiation treatment during the last 4 weeks.
References
Publications (0)
Data not yet available