Clinical trial · Interventional
Dose-dependent Effect of Fentanyl on Cough Attenuation During Emergence From General Anaesthesia
NCT01308320CI-TRIAL-00004504completedPhase 4ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Fentanyl is expected to suppress tracheal tube-induced cough during emergence from general anaesthesia through binding to its receptors in the brainstem. However, it has not been proven if fentanyl has a complication-free, dose-dependent effect on cough suppression during emergence from sevoflurane anaesthesia. The purpose of this study is to evaluate the relationship between fentanyl doses and cough suppression during emergence from sevoflurane anaesthesia.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Thyroid Neoplasm | Thyroid Gland Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| fentanyl citrate | Drug | — | UNRESOLVED |
| saline | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- type
- PLACEBO_COMPARATOR
- label
- saline
- description
- control group
- interventionNames
- Drug: saline
- type
- ACTIVE_COMPARATOR
- label
- F1 group
- description
- F1 group : fentanyl 1 mcg/kg
- interventionNames
- Drug: fentanyl citrate
- type
- ACTIVE_COMPARATOR
- label
- F1.5 group
- description
- F1.5 group : fentanyl 1.5 mcg/kg
- interventionNames
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 20 Years
- Maximum age
- 59 Years
Show eligibility criteria text
Inclusion Criteria: * the patients undergoing general anaesthesia for elective thyroidectomy due to thyroid neoplasm. * ASA I-II. * 20-59 years old. * female only. Exclusion Criteria: * signs of difficult intubation. * risks for perioperative pulmonary aspiration. * history of chronic respiratory disease. * recent upper respiratory track infection. * previous and recent smoking history
References
Publications (2)
- BACKGROUNDTagaito Y, Isono S, Nishino T. Upper airway reflexes during a combination of propofol and fentanyl anesthesia. Anesthesiology. 1998 Jun;88(6):1459-66. doi: 10.1097/00000542-199806000-00007. PMID 9637637
- BACKGROUNDNishina K, Mikawa K, Maekawa N, Obara H. Fentanyl attenuates cardiovascular responses to tracheal extubation. Acta Anaesthesiol Scand. 1995 Jan;39(1):85-9. doi: 10.1111/j.1399-6576.1995.tb05597.x. PMID 7725888