Clinical trial · Interventional
High Intensity Focused Ultrasound (HIFU) for Parathyroid Adenoma
NCT01291498CI-TRIAL-00030824terminatedN/AResults postedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): The manufacturer is not currently supporting research in this indication.
Summary
Brief summary (as posted)
This study aims to determine whether HIFU treatment is a safe and effective alternative to an operation to remove all or part of the affected gland. The objective is to achieve biochemical cure (assessed by normal calcium level in the blood at six weeks, six months and one year after therapy) without affecting the patient's voice or ability to swallow.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Parathyroid Adenomas | Parathyroid Gland Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| High Intensity Focused Ultrasound | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- OTHER
- label
- HIFU Treatment
- description
- High Intensity Focused Ultrasound. This is not a comparative study
- interventionNames
- Device: High Intensity Focused Ultrasound
Primary outcomes (1)
- measure
- Eucalcaemia
- timeFrame
- 12 months post-treatment
- description
- Calcium in the blood is measured from venepuncture
Secondary outcomes (2)
- measure
- Eucalcaemia
- timeFrame
- Six weeks post-treatment.Six month data were also intended to be reported, however, six month data were not analyzed because only one subject was entered and this subject was withdrawn from the study before six months after treatment.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Primary Hyperparathyroidism (PHPT) * Moderate/severe hypercalcaemia (Ca\>2.8mmol/L) * Positive sestamibi scan demonstrating a cervical parathyroid adenoma * Adenoma visible on ultrasound scan Exclusion Criteria: * Large adenoma (\>15mm) * Deep adenoma (\>20mm from skin surface * Familial disease (eg members of MEN-1 families) * Inability to complete questionnaires in English without making mistakes or needing help with translation
References
Publications (0)
Data not yet available
No reference posted for this study.