A Pilot Study of 123I-MIP-1072 SPECT/CT Imaging With Optional Compact Gamma Camera Probe Imaging in Men With Prostate Cancer Undergoing Prostatectomy

Inclusion Criteria:

* Participant must be scheduled to undergo standard of care prostatectomy for presumed localized prostate cancer at the NIH Clinical Center.
* Have had or will undergo multiparametric endorectal coil 3T MR at the NIH clinical center
* Recent (within 12 months of study entry) trans-rectal biopsy indicating the presence of adenocarcinoma of the prostate gland
* Participant must be 18 years or older.
* ECOG Performance grade of 0 to 2. (see Appendix 1)
* Ability to understand and provide informed consent. All subjects must sign a document of informed consent indicating their understanding of the investigational nature and risks of the study before any protocol related studies are performed.
* Participants of childbearing potential must agree to use an acceptable form of birth control, defined as abstinence, barrier or other acceptable, effective contraceptive method until 7 days after the infusion of study drug.

Exclusion Criteria:

* Participants for whom participating would significantly delay the scheduled standard of care therapy.
* Subjects must not have prostate biopsies performed within 12 weeks before imaging; or within 8 weeks before imaging providing that the absence of hemorrhage is confirmed by MR imaging.
* SGOT and SGPT ≥ 2 x of the upper limits of normal; total bilirubin, of ≥ 1.5 x the upper limits of normal or ≥ 3.0 mg/dl in patients with Gilbert's syndrome.
* Administered a radioisotope within 5 physical half lives prior to study enrollment.
* Patients with severe claustrophobia unresponsive to oral anxiolytics
* Subjects weighing ≥350 lbs or are unable to fit within the imaging gantry
* Subjects who have received androgen deprivation therapy.
* Subjects with any medical condition or other circumstances that, in the opinion of the Investigator, would significantly decrease obtaining reliable data, achieving study objectives or completing the study.