Clinical trial · Interventional
CLL Empirical Antibiotic Regimen
A Phase II Trial of Broad Spectrum Antibiotic Therapy for Early Stage, Non-progressive Chronic Lymphocytic Leukaemia Without Adverse Prognostic Factors
NCT01279252CI-TRIAL-00036769CLEARcompletedPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to evaluate whether patients with previously untreated, early stage CLL respond to empirical broad spectrum antibiotics and therefore test the hypothesis that occult bacterial infections are involved in the induction and maintenance of CLL.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Chronic Lymphocytic Leukaemia (CLL) | Chronic Lymphocytic Leukemia | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| metronidazole, clarithromycin, ciprofloxacin and lansoprazole | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Antibiotic regimen
- interventionNames
- Drug: metronidazole, clarithromycin, ciprofloxacin and lansoprazole
Primary outcomes (1)
- measure
- Overall response rate [Complete Remission (CR) + Partial Remission (PR)]
- timeFrame
- 6 months
Secondary outcomes (2)
- measure
- Incidence of CTCAE grade 2 or above treatment related toxicity
- timeFrame
- From day 1 to 6 weeks
- measure
- Bone marrow Minimal Residual Disease (MRD) status in patients who achieve CR
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age \> 18 * ECOG performance status of 2 or less. * CLL with a diagnostic score of 4 or 5. * Clinical stage A disease. * No disease progression over a minimum of 1 month prior to commencement of therapy. * Less than 2 adverse prognostic factors. * Absence of adverse cytogenetics. * Expected survival \> 6 months. * Able to give informed consent. * No clinical evidence of active infection at the time of study entry. * No known allergy to any of the study medications. * Renal and liver function tests within normal limits. Exclusion Criteria: * Disease progression during screening period. * Known positivity for HIV types 1 or 2. * Active infection at the time of screening. * Pregnancy or lactation. * Females of childbearing potential† and males not willing to practice an effective method of contraception whilst receiving the antibiotic regimen and for 4 weeks after the last dose. * Concomitant medication likely to produce serious interaction with study drugs including warfarin type oral anticoagulants and anti-epileptics.
References
Publications (0)
Data not yet available
No reference posted for this study.