Effects of Maraviroc (MVC) on HIV-related Kaposi's Sarcoma (KS)

Inclusion Criteria:

* HIV-1 infected, as documented by any licensed ELISA test kit and confirmed by Western blot at any time prior to study entry. HIV-1 culture, HIV-1 antigen, plasma HIV-1 RNA, or a second antibody test by a method other than ELISA is acceptable as an alternative confirmatory test.
* Active biopsy confirmed KS
* Screening plasma HIV RNA \< 75 copies/mL
* Patients have unremitting KS. Unremitting is defined as having active biopsy confirmed KS in spite of having had sustained HIV RNA \< 75 copies/mL for 24 prior months. Isolated values that are detectable but \< 500 copies will be allowed as long as the plasma HIV RNA levels before and after this time point are undetectable.
* \>90% adherence to therapy within the preceding 30 days, as determined by self-report.
* Both male and female subjects are eligible. Females of childbearing potential must have a negative serum pregnancy test at screening and agree to use a double-barrier method of contraception throughout the study period.
* Ability and willingness of subject or legal guardian/representative to provide informed consent

Exclusion Criteria:

* Patients who are intending to modify antiretroviral therapy in the next 24 weeks for any reason.
* Serious illness requiring hospitalization or parental antibiotics within preceding 3 months.
* Concurrent treatment with immunomodulatory drugs or therapies, or exposure to any immunomodulatory drug or therapy in past 16 weeks.
* Prior exposure to CCR5 inhibitors
* Screening absolute neutrophil count \<1,000 cells/mm3, platelet count \<50,000 cells/mm3, hemoglobin \< 8mg/dL, estimated creatinine clearance \<40 mL/minute.
* Elevated transaminases greater than 2.5 times the upper limit of normal.
* Evidence of cirrhosis
* Pregnant or breastfeeding women
* Use of both Tenofovir and Didanosine in current antiretroviral therapy regimen.
* Local therapy for any KS index lesion in preceding 60 days, unless lesion has clearly progressed with enlargement since the local therapy