Clinical trial · Interventional
A Comparison of Remifentanil and Dexmedetomidine for Craniotomy Perioperative Hemodynamics and Postoperative Pain
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This will be a randomized blinded clinical trial. Patients will be randomized to receive either a remifentanil or dexmedetomidine infusion for general anesthesia. The anesthesia team will know the result of randomization at induction. Data will be gathered by research personnel who will be blinded to the anesthetic method used. Patients will be blinded to the anesthetic they receive till they are discharged from the PACU when they will have the option to be unblinded. The Data Safety and -Toxicity Committee will review all serious adverse events and toxicity reports as well as annual reviews.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Adult Intracranial Tumor | Adult Intracranial Neoplasm | ALIAS | 0.90 |
| Adult Solid Tumor | Adult Solid Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Dexmedetomidine | Drug | — | UNRESOLVED |
| Remifentanil | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Remifentanil
- description
- Remifentanil 0.08-0.15MCG/KG/MIN INFUSION THROUGHOUT PROCEDURE BASED ON HEMODYNAMICS
- interventionNames
- Drug: Remifentanil
- type
- ACTIVE_COMPARATOR
- label
- Dexmedetomidine
- description
- a loading dose of dexmedetomidine was given at 0.5 to 1 micrograms/kg ideal body weight over 15 minutes, followed by an infusion at 0.2 to 0.7 micrograms/kg/hour.
- interventionNames
- Drug: Dexmedetomidine
Primary outcomes (3)
- measure
- Hemodynamics
- timeFrame
- 15, 30, 45, 60, and 90 minutes after extubation.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: Patients who undergo general anesthesia for elective surgical excision of a brain tumor with following specifications: * Age: Older than 18 * Primary and redo cases will be included * Duration of surgery not exceeding 6 hrs. Exclusion Criteria: * Patient refusal * Emergency craniotomy * Morbid obesity * Uncontrolled hypertension - DBP more than 110 * Cardiac conduction defects * Patients with chronic pain.
References
Publications (0)
Data not yet available