Efficacy and Safety of Bevacizumab/Temsirolimus Combination to Treat Advanced Renal Cell Carcinoma

Inclusion Criteria:

* Adult patients (18th year of age completed)
* Signed and dated written informed consent form prior to any procedures related to this protocol.
* Histologically confirmed advanced clear cell renal cancer.
* Measurable disease.
* Failure of first line anti-VEGF treatment.
* Performance status 0-2, according to Eastern Cooperative Oncology Group (ECOG) .
* Satisfactory hematological parameters:

  * White blood cell count \> 4000 mm3.
  * Platelet count 100000/mm3.
  * Neutrophil blood cell count \> 1200/ mm3 .
  * Hemoglobin \> 9,0 g/dL (can be achieved with red blood cell transfusion).
* Satisfactory biochemical parameters:

  * Serum creatinine \< 2 x Upper Limit of Normal(ULN)
  * Aspartate Aminotransferase (AST)\<2,5 x ULN
  * Alanine Transaminase (ALT)\< 2,5 x ULN.
  * Bilirubin \<2 x ULN
* (For female patients) Absence of pregnancy (negative pregnancy test for women of reproductive age before enrollment).
* (For female patients) Non-lactating women.
* Use of efficient contraceptive measures (women and men) to prevent possible pregnancy of female patient or female partner of a male patient during treatment and until 6 months after the end of treatment.

Exclusion Criteria:

* Prior treatment with mTOR inhibitor.
* Major surgery (including open biopsy) or insufficient recovery or existence of major trauma within 4 weeks before enrollment.
* Uncontrolled hypertension.
* Active infection requiring systemic treatment within 4 weeks prior to enrollment.
* Minor surgery (for instance, catheter placement) within 2 days before enrollment.
* Scheduled major surgery within the treatment period.
* Medical history in the last 6 months prior to enrollment of significant cardiovascular disease, diabetes, cardiac infarction, unstable angina, uncontrolled arrhythmia or significant heart failure.
* Indications of uncontrolled metastases or disease progression in CNS lesions (the suspicion of uncontrolled metastases or disease progression should be eliminated by imaging techniques within 14 days prior to enrollment).
* Medical history in the last 5 years prior to enrollment of any other malignancies (excluding the basal or squamous skin cell carcinoma or in situ carcinoma of the cervix).
* History of non-healing wound including active gastric ulcer.
* History of fistula in the last 6 months prior to enrollment.
* History of gastrointestinal perforations.
* Patient incapacity (for psychiatric or social reasons) to conform with the protocol.
* History of hemorrhagic predisposition.
* History of hypersensitivity to the medications under investigation.
* Significant proteinurea.
* Prior immunotherapy within 4 weeks prior to enrollment.
* Prior radiation treatment within 2 weeks prior to enrollment.
* Concomitant medication with inducers or strong inhibitors of the coenzyme CYP3A4 (see Appendix 5 for an indicative list of active compounds).
* Concurrent participation in other interventional clinical trials with investigational medicinal products.
* History of chronic interstitial lung disease.