Clinical trial · Interventional
Fractional CO2 Laser Assisted Photodynamic Therapy
Conventional Versus Fractional CO2 Laser Assisted Photodynamic Therapy for Basal Call Carcinomas and Actinic Keratoses
NCT01260987CI-TRIAL-00018718completedPhase 2 / Phase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Nodular Basal Cell Carcinomas: Compare the efficacy and safety of conventional versus fractional laser assisted PDT for difficult to treat nodular cell carcinomas in the face. Actinic keratosis: Compare the efficacy and safety of conventional versus fractional laser assisted PDT for moderate to severe actinic keratoses located in the face and on the hands.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Actinic Keratosis | — | UNRESOLVED | — |
| Basal Cell Carcinoma | Basal Cell Carcinoma | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Conventional photodynamic therapy | Drug | — | UNRESOLVED |
| Fractional CO2 laser assisted PDT | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- ACTIVE_COMPARATOR
- label
- AK split-face treatment
- description
- Split-face treatment of two symmetrical areas with moderate to severe actinic keratoses. One area is treated with conventional PDT the other with fractional laser assisted PDT.
- interventionNames
- Drug: Conventional photodynamic therapy
- Drug: Fractional CO2 laser assisted PDT
- type
- ACTIVE_COMPARATOR
- label
- Fractional laser assisted PDT for BCC
- description
- Difficult to treat nodular basal cell carcinomas in the face is pretreated with fractional CO2 laser followed by methyl-aminolevulinate PDT.
- interventionNames
- Drug: Fractional CO2 laser assisted PDT
- type
- ACTIVE_COMPARATOR
- label
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age 18 or older * Skin type I-III * Fertile women using secure birth control * Moderate to severe actinic keratoses in the face or on the hands, * Difficult to treat nodular basal cell carcinomas in the face Exclusion Criteria: * Pregnancy or breast feeding patients * Patients with porphyria * Patients with Gorlins syndrome * Patients with a tendency to produce hypertrophic scars or keloids * Patients with known allergy to Metvix * Patients who are not considered able to follow the treatment protocol (e.g. severely alcoholic, dementia, mentally ill etc.) * Patients with pigmented or morphea basal cell carcinomas * Know herpes simplex virus infection in treatment areas
References
Publications (0)
Data not yet available
No reference posted for this study.