Clinical trial · Interventional
Hypertensive Ambulatory Trial to Compare the Efficacy of HCTZ and Lisinopril
Series of Single Patient Trials Comparing the Efficacy Between the Most Commonly Prescribed Thiazide Diuretic in the US, Hydrochlorothiazide, and Lisinopril for the Treatment of Stage 1 Hypertension.
NCT01258764CI-TRIAL-000179741HATcompletedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this trial is to evaluate if an objective clinical decision of anti-hypertensive therapy can be made using an N-of-1 (single patient) trial design.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hypertension | — | UNRESOLVED | — |
| Hypertension, Grade 1 | — | UNRESOLVED | — |
| Hypertension Treatment | — | UNRESOLVED | — |
| N of 1 Study Design | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Hydrochlorothiazide | Drug | — | UNRESOLVED |
| Lisinopril | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Lisinopril
- interventionNames
- Drug: Lisinopril
- type
- ACTIVE_COMPARATOR
- label
- Hydrochlorothiazide
- interventionNames
- Drug: Hydrochlorothiazide
Primary outcomes (1)
- measure
- Blood pressure control defined as 24-hour ambulatory systolic and diastolic pressure average below 135/85 mmHg.
- timeFrame
- After 14 week study period with assessment of patient specific data
Secondary outcomes (1)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Diagnosis of Grade 1 Hypertension * Treatment naïve * GFR \> 60 within previous 3 months * Urinary microalbumin level normal during previous 3 months Exclusion Criteria: * Pregnancy (Fetal morbidity and mortality may occur with the use of ACE inhibitors.) * Uncontrolled Hyperthyroidism * Sleep Apnea * Primary Aldosteronism * Renovascular Disease * Cushing's Syndrome or steroid therapy * No evidence of end organ damage * EKG with evidence of LVH within previous 3 months * Collagen Vascular Disease * Current Smoker
References
Publications (0)
Data not yet available
No reference posted for this study.