AKT Inhibitor MK-2206 in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia

Inclusion Criteria:

* Patients must have histologically or cytologically confirmed AML other than acute promyelocytic leukemia (2008 World Health Organization (WHO) classification)
* Patients must have persistent or relapsing disease requiring 2nd salvage therapy (e.g. treatment for second or higher relapse or for primary refractory disease after failure of two prior treatment regimens); duration of prior complete remission \< 12 months if not refractory disease; patients with prior autologous and allogeneic hematopoietic stem cell transplantation are eligible if patients are off immunosuppression for \>1 month and have no evidence of active graft versus host disease (GVHD) except grade 1 skin GVHD
* Patients age \>= 60 years with less than two prior treatment regimens not candidates for or have refused standard chemotherapy, excluding subjects with acute promyelocytic leukemia (APL) or with favorable cytogenetic abnormalities \[inv16, t(8;21)\]
* Patient at the time of enrollment should not be a candidate for allogeneic stem cell transplantation
* The Eastern Cooperative Oncology Group (ECOG) performance status =\< 2
* Serum creatinine or calculated creatinine clearance =\< 1.5 \* upper limit of normal (ULN) OR \>= 60 mL/min for patients with creatinine levels \> 1.5 \* institutional ULN
* Serum total bilirubin =\< 2 \* ULN OR direct bilirubin =\< ULN for patients with total bilirubin levels \> 2 \* ULN, unless elevation is thought to be due to hepatic infiltration by AML, Gilbert's syndrome, or hemolysis
* asparate aminotransferase (AST/SGOT) and alanine aminotransferase (ALT /SGPT) =\< 2.5 \* ULN or =\< 5 \* ULN unless considered to be secondary to leukemic involvement
* Fasting serum glucose =\< 150 mg/dl
* HBA1c =\< 9%
* Female patient of childbearing potential must have a negative serum or urine pregnancy test beta- Human chorionic gonadotropin (hCG) within 72 hours prior to receiving the first dose of study medication; the effects of MK-2206 on the developing human fetus at the recommended therapeutic dose are unknown; for this reason women of childbearing potential and men must use two forms of contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation; should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, the patient should inform the treatment physician immediately
* Patient, or the patient"s legal representative, has voluntarily agreed to participate by giving written informed consent
* Patient is able to swallow tablets and has no surgical or anatomical condition that will preclude the patient from swallowing and absorbing oral medications on an ongoing basis

Exclusion Criteria:

* Patients may not be receiving any other investigational agents
* Major surgery, other than diagnostic surgery, within 4 weeks prior to Day 1, without complete recovery
* Active uncontrolled infection
* Systemic chemotherapy (with the exception of hydroxyurea) within 14 days (or within 5 half-lives for an investigational agent) prior to first dose of study drug, unless there is evidence of rapidly progressive disease; persistent chronic clinically significant toxicities from prior chemotherapy must not be \> grade 1
* Patients with central nervous system (CNS) involvement
* Patient has known hypersensitivity to the components of study drug or its analogs
* Uncontrolled congestive heart failure, unstable angina pectoris
* Uncontrolled cardiac arrhythmia
* History or current evidence of a myocardial infarction during the last 6 months
* corrected Q-T interval (QTc) prolongation \> 450 msec (Bazett's Formula)
* Congenitally long QT syndrome, has received any marketed or experimental compound in the last 4 weeks or 5 half lives (whichever is shorter) prior to entering the study with possible or known effects of QT prolongation
* Patient with symptomatic bradycardia, or a history of clinically significant bradyarrhythmias such as sick sinus syndrome, 2nd degree AV block (Mobitz Type 2)
* Patient with uncontrolled hypertension (i.e., i.e., sustained systolic blood pressure \>= 160 or diastolic \>= 90); patients who are controlled on antihypertensive medication will be allowed to enter the study
* Patient with poorly controlled diabetes defined as HBA1C \> 9%
* Patient is pregnant or breastfeeding, or expecting to conceive or father children within the projected duration of the study
* Patient is known to be Human Immunodeficiency Virus (HIV)-positive with history of AIDS defining conditions; or CD4 cells prior to leukemia onset =\< 400 cells/mm\^3; or patients receiving antiretroviral therapy that affects CYP3A4 such as protease inhibitors, efavirenz, nevirapine, or zidovudine
* Patient has active Hepatitis B or C or active Hepatitis A