Clinical trial · Interventional
Compliance: Role Emerges for Success in Chronic Myelogenous Leukaemia (CML): Evaluation aND Optimisation
CRESCENDO (Compliance: Role Emerges for Success in CML: Evaluation aND Optimisation): A Prospective, Multi-center, Phase IV Study to Assess the Compliance in Patients With Philadelphia Chromosome-positive (Ph+) and/or BCR-ABL Positive Chronic Myelogenous Leukaemia (CML) Under Long-term Imatinib Therapy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study on patient's compliance in clinical workaday life aims to assess and to improve CML treatment in Germany by means of adherence supporting measures and to increase adherence awareness by physicians and patients.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Chronic Myelogenous Leukemia (CML) | Chronic Myeloid Leukemia, BCR-ABL1 Positive | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| compliance supporting measures | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- OTHER
- label
- patient diary
- description
- compliance supporting measure: patients uses patient diary from month 6 to 12
- interventionNames
- Other: compliance supporting measures
- type
- OTHER
- label
- Information service "Leben mit CML"
- description
- compliance supporting measure: patient uses the Information service "Leben mit CML"
- interventionNames
- Other: compliance supporting measures
Primary outcomes (1)
- measure
- Patients compliance
- timeFrame
- 12 months
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Adult (\> 18 years) CML patients in the chronic phase * Medical history of cytogenetically confirmed CML-CP by the presence of the Philadelphia chromosome on bone marrow aspirates (a minimum of 20metaphases is required; FISH cannot be used); Philadelphia chromosome negative but BCR- ABL-positive CML patients can be included * ECOG performance status of \< 2 * Imatinib treatment for at least 1 year and showing CCyR or MMR * Prior treatment with chemotherapeutics such as hydroxyurea or interferon- alpha is allowed * Prior periods of accelerated phases are allowed * Negative pregnancy test for female patients of childbearing potential within 7 days before initiation of study drug * Ability to understand and willingness to sign a written informed consent document prior to any study related screening procedures * Written informed consent, including the consent to be called for interviews by the external, neutral institution. Exclusion Criteria: * Patients with prior blast crisis or stem cell transplantation * Patients with severe medical condition(s) that in the discretion of the investigator prohibits participation in the study (e.g., clinically significant heart diseases, uncontrolled diabetes, active or uncontrolled infection, impaired gastrointestinal function/diseases) * Treatment with drugs or substances, especially those known to modify the cytochrome P450 activity, should be either discontinued or exchanged by different medication (see link for complete list of these medications: http://medicine.iupui.edu/flockhart/table.htm.) * Pregnant or breastfeeding women * Male or female of childbearing potential unwilling to use contraceptive precautions throughout the trial
References
Publications (0)
Data not yet available