Escalating Doses of Thalidomide in Conjunction With Bortezomib and HIgh Dose Melphalan for BSCT

Inclusion Criteria:

* Each patient must meet all of the following inclusion criteria to be enrolled in the study:
* Voluntary written informed consent before performance of any study-related procedure not part of normal medical care, with the understanding that consent may be withdrawn by the subject at any time without prejudice to future medical care
* Female subject is either post-menopausal or surgically sterilized or willing to use an acceptable method of birth control as described in the S.T.E.P.S program. Participation in the program is required.
* Male subject agrees to use an acceptable method for contraception for the duration of the study as described in the S.T.E.P.S program. Participation in the program is required.
* Confirmed diagnosis of multiple myeloma, or plasma cell leukemia.
* Show progression of disease after a previous dose-intense cycle of melphalan, or less than a complete response after a prior cycle of dose-intense melphalan. Patients may have received more than on prior autologous transplant with high-dose melphalan.
* May have received intervening therapies after disease progression after dose-intense melphalan and before enrollment in this protocol.
* Recovery from complications of salvage therapy, if administered.
* Age: ≥18 yrs but \<76 yrs at the time of melphalan administration.
* Gender: There is no gender restriction.
* Availability of \>2x106 autologous peripheral blood CD34+ cells/kg or a syngeneic donor meeting eligibility criteria for syngeneic donation.

  1. Syngeneic transplantation is preferred.

Exclusion Criteria:

* Patients meeting any of the following exclusion criteria are not to be enrolled in the study.
* Cytotoxic chemotherapy or radiotherapy within 21 days of initiating treatment in this study.
* Prior dose-intense therapy within 56 days of initiating treatment in this study.
* Uncontrolled bacterial, viral, fungal or parasitic infections .
* Uncontrolled CNS metastases.
* Known amyloid deposition in heart.
* Organ dysfunction:

LVEF \<40% or cardiac failure not responsive to therapy. DLCO \<50% of predicted and/or receiving supplementary continuous oxygen. Evidence of hepatic synthetic dysfunction, or total bilirubin \>2x or AST \>3x ULN.

Measured creatinine clearance \<20 ml/min. Sensory peripheral neuropathy grade 4 within 14 days of enrollment.

* Karnofsky score \<70% unless as a result of bone disease directly caused by myeloma.
* Life expectancy limited by another co-morbid illness.
* Diagnosed or treated for another malignancy within 2 years of enrollment, with the exception of complete resection of basal cell carcinoma or squamous cell carcinoma of the skin, an in situ malignancy, or low-risk prostate cancer after curative therapy
* Female subject is pregnant or breast-feeding (women) or unwilling to use acceptable birth control methods (men or women) for twelve months after treatment or unwilling to participate in the S.T.E.P.S program.
* Documented hypersensitivity to melphalan, thalidomide or to bortezomib, boron or mannitol or any components of the formulation
* Patients unable or unwilling to provide consent
* Myocardial infarction within 6 months prior to enrollment or has New York Heart Association (NYHA) Class III or IV heart failure, uncontrolled angina, severe uncontrolled ventricular arrhythmias, or electrocardiographic evidence of acute ischemia or active conduction system abnormalities. Prior to study entry, any ECG abnormality at screening has to be documented by the investigator as not medically relevant.
* Patient has received other investigational drugs with 14 days before enrollment
* Serious medical or psychiatric illness likely to interfere with participation in this clinical study.