Clinical trial · Interventional
The Effects of Physical Activity and Low-Dose Ibuprofen on Cognitive Function in Cancer Patients
A Phase II Study of the Effects of Physical Activity and Low-Dose Ibuprofen on Cognitive Function in Cancer Patients Undergoing Chemotherapy
NCT01238120CI-TRIAL-00051608completedPhase 2Results postedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This research seeks to determine if a combination of low-dose ibuprofen along with a structured home-based walking and progressive resistance exercise program, EXCAP, will be effective in reducing cognitive difficulties among cancer patients receiving chemotherapy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer-related Cognitive Difficulties | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Home-Based Exercise | Behavioral | — | UNRESOLVED |
| Ibuprofen | Drug | Ibuprofen | ALIAS |
| Placebo | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- type
- ACTIVE_COMPARATOR
- label
- Placebo and Home-Based Exercise
- description
- 200mg placebo (taken twice a day at least 8 hours apart) for a period of 6 weeks and a progressive walking and resistance band exercise program called Exercise for Cancer Patient (EXCAP) for a period of 6 weeks.
- interventionNames
- Behavioral: Home-Based Exercise
- Drug: Placebo
- type
- ACTIVE_COMPARATOR
- label
- Ibuprofen 200mg BID, Home-Based Exercise
- description
- 200mg ibuprofen (taken twice a day at least 8 hours apart) and a progressive walking and resistance band exercise program called Exercise for Cancer Patient (EXCAP) for a period of 6 weeks.
- interventionNames
- Drug: Ibuprofen
- Behavioral: Home-Based Exercise
- type
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Must report cognitive difficulties of 3 or higher on a 0-10 scale * Must provide informed consent * Be able to read English * Have a primary diagnosis of cancer * Be able to swallow medication * Women of child-bearing potential must not be pregnant or become pregnant during the 6 week study * Agree not to take NSAIDs during the 6 week intervention period * Be scheduled to receive at least 2 additional cycles of oral or IV chemotherapy over the 42-day study period. * Must have the approval of their treating physician to begin the exercise program and receive the ibuprofen * Must be over 18 years of age Exclusion Criteria: * Currently taking a consistent dosage of a NSAID at least 3 days a week for the last 3 months that is over 400mg daily * Have an allergy to ibuprofen * Be identified as in active or maintenance stage of exercise behavior as assessed by the single-item exercise stages of change short form * have physical limitations that contraindicate participation in sub-maximal physiological fitness testing or a low to moderate home-based walking and progressive resistance program * have a history of peptic ulcer disease within the last 12 months * Diagnosed with a neurodegenerative disease * Had a myocardial infraction within the past 6 months * Patients with a neutropenic episode during the first cycle of chemotherapy or at high risk for a neutropenic episode during future chemotherapy cycles at the treating physicians discretion * Have confirmed metastatic disease to the central nervous system * Have been hospitalized for a major psychiatric illness within the last 5 years
References
Publications (0)
Data not yet available
No reference posted for this study.