Clinical trial · Observational

Biomarkers in Tissue Samples From Young Patients With Acute Myeloid Leukemia

Promoter Methylation in MLL-Rearranged Childhood AML

NCT01229956CI-TRIAL-00022290completedClinicalTrials.gov clinicaltrialsPublishedExplore in graph →

Summary

Brief summary (as posted)

RATIONALE: Studying samples of tissue from patients with cancer the in laboratory may help doctors identify and learn more about biomarkers related to cancer. PURPOSE: This research study is studying biomarkers in tissue samples from young patients with acute myeloid leukemia.

Conditions

Conditions (1)

Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.

Condition (as posted)	Mapped entity	Match	Confidence
Leukemia	Leukemia	ONTOLOGY_EXACT	0.90

Interventions

Interventions (5)

Intervention	Type	Mapped drug	Match
DNA methylation analysis	Genetic	—	UNRESOLVED
gene expression analysis	Genetic	—	UNRESOLVED
laboratory biomarker analysis	Other	—	UNRESOLVED
microarray analysis	Genetic	—	UNRESOLVED
reverse transcriptase-polymerase chain reaction	Genetic	—	UNRESOLVED

Design

Arms and outcomes

Arms (0)

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Primary outcomes (1)

measure
Identification of differential patterns of promoter hypermethylation and gene expression in pairwise comparisons with other cohorts and normal controls

Eligibility

Eligibility (as posted)

Sex: All
Minimum age: 1 Year
Maximum age: 18 Years

Show eligibility criteria text

DISEASE CHARACTERISTICS:

* Available cryopreserved cells from diagnosis

  * At least 2 x 10\^7 viably cryopreserved cells
* One of the following biologically defined cytogenetics/molecular cohorts:

  * t(9;11)
  * t(11;19)
  * Other 11q23 translocations
  * Normal cytogenetics

PATIENT CHARACTERISTICS:

* Not specified

PRIOR CONCURRENT THERAPY:

* Not specified

References

Publications (0)

Data not yet available

No reference posted for this study.