Clinical trial · Interventional
Mobilization by Plerixafor of Haematopoietic Stem Cells in Children
NCT01225419CI-TRIAL-00015018MEP1completedPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a prospective Phase II, monocentre study.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Children Cancer, Solid Tumor | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Plerixafor, mozobil | Drug | Plerixafor | ALIAS |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Percentage of the children to whom 5.106 cells CD34 + / kg can be collected in 2 masses blood treated (one cytapheresis).
- timeFrame
- between H4 and H9 at day 0
Secondary outcomes (5)
- measure
- Describe the kinetics of mobilization of the hematopoietic progenitor at the child in situation of hematopoietic stable state after a subcutaneous injection of plerixafor
- timeFrame
- between the injection and the apheresis at day 0
- measure
- Describe the pharmacokinetics of the plerixafor at the child
- timeFrame
- between the injection and the apheresis at day 0
- measure
- Describe the side effects
- timeFrame
- day 0 to day 3
Eligibility
Eligibility (as posted)
- Sex
- All
- Maximum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * 0 to 18 years old * Solid malign tumor * Lansky score ≥ 70% * Indication of hematopoietic stem cell taking by cytapheresis for extensive chemotherapy followed by one or several reinjections of hematopoietic stem cells Exclusion Criteria: * Administration of hematopoietic growth factors in 8 days preceding the injection of Plerixafor. * Contraindication in the cytapheresis or in the extensive chemotherapy. * Clinical or biological state dissuading the realization of the cytapheresis * Chemotherapy in 15 days preceding the injection of plerixafor or neutrophils \< 1500/mm3
References
Publications (0)
Data not yet available
No reference posted for this study.