A Study, Combination, Immunologic Study of LTX-315 as Adjunct to GV1001 in Patients Following Curative Surgery for Carcinoma

Inclusion Criteria:

* Curative surgery for carcinoma performed at least three months prior to treatment start
* Age ≥18 years
* ECOG Performance status (PS): 0
* Life expectancy: at least 3 months
* Laboratory requirements:

  * White Blood Count (WBC) ≥ 3 x 109/L
  * Absolute neutrophil count (ANC) ≥ 1.5 x 109/L
  * Platelet count ≥ 100 x 109/L
  * Haemoglobin ≥ 10.0 g/dL
  * Total bilirubin level ≤ 1.5 ULN
  * AST and ALT ≤ 2.5 x ULN
  * Creatinine ≥ 1.5 ULN
  * Albumin \> 30 g/L
* No expectation of anti-cancer therapy or immunotherapy during the trial period, hormone therapy given as adjunctive or contraceptive therapy is permitted
* Must be willing to practice acceptable barrier methods of birth control to prevent pregnancy
* The patient is willing and able to comply with the protocol and agrees to return to the hospital for follow-up visits and examination
* The patient has been fully informed about the study and has signed the informed consent form

Exclusion Criteria:

* Has received an investigational drug within 4 weeks prior to study drug administration, or is scheduled to receive one during the treatment or the post-treatment period
* Has received immunotherapy or been vaccinated within 12 weeks prior to study drug administration or has not recovered from adverse events due to such agents
* Has received external radiotherapy or cytotoxic chemotherapy within the last 4 weeks prior to study drug administration, or has not recovered from adverse events (\< Grade 1) due to agents administered more than 4 weeks earlier
* Has received imiquimod within 12 weeks prior to study drug administration or has not recovered from associated adverse events
* Is currently on any agent with a known effect on the immune system
* Has any other serious illness or medical condition such as but not limited to:

  * Any uncontrolled infection or infection requiring antibiotics
  * Uncontrolled cardiac failure Classification III or IV (New York Heart Association)
  * Uncontrolled systemic and gastro-intestinal inflammatory conditions
  * Bone marrow dysplasia
  * History of auto-immune disease
  * History of adverse reaction to vaccines
* Known history of positive tests for HIV/AIDS, hepatitis B or C
* Is pregnant or breastfeeding