Clinical trial · Interventional
Computerized Intervention for Amelioration of Cognitive Late Effects Among Childhood Cancer Survivors
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Children treated for a brain tumor (BT) or acute lymphoblastic leukemia (ALL) show elevated rates of working memory impairment. Working memory (WM) is the ability to hold and manipulate information online; for example, when an individual mentally rehearses a phone number in order to dial it without writing it down. A computer-based working memory intervention has been successful in children diagnosed with ADHD and stroke survivors. Individuals participating in the intervention showed improvements on working memory measures as well as more complex problem solving skills. Neuroimaging (brain scans) conducted before and after training showed changes in brain activation suggestive of underlying changes in brain systems that support working memory. This study investigates the effectiveness of this computer-based working memory intervention for childhood cancer survivors.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Acute Lymphoblastic Leukemia | Acute Lymphoblastic Leukemia | ONTOLOGY_EXACT | 0.98 |
| Brain Tumor | Brain Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Computerized working memory training program (control) | Behavioral | — | UNRESOLVED |
| Computerized working memory training program (intervention) | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- OTHER
- label
- Intervention Group
- description
- Children treated for a brain tumor (BT) or acute lymphoblastic leukemia (ALL) will complete the computerized working memory training program (intervention).
- interventionNames
- Behavioral: Computerized working memory training program (intervention)
- type
- OTHER
- label
- Control Group
- description
- Children treated for a brain tumor (BT) or acute lymphoblastic leukemia (ALL) will complete the computerized working memory training program (control).
- interventionNames
- Behavioral: Computerized working memory training program (control)
Primary outcomes (1)
- measure
- This study will measure working memory, attention and executive functions
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 8 Years
- Maximum age
- 16 Years
Show eligibility criteria text
Inclusion Criteria for Screening Phase: * Received CNS-directed treatment (intrathecal chemotherapy or cranial irradiation) for a BT or ALL * Infratentorial tumor location (for the BT cohort) * Off treatment for at least one year with no evidence of recurrent or progressive disease * Age 8-16 years inclusive at the time of enrollment * English as the primary language * Research participant and one parent willing to participate and provide consent/assent according to institutional guidelines Exclusion Criteria for Screening Phase * Significant impairment in global intellectual functioning (estimated or full scale IQ \< 70 based on standardized testing routinely conducted on primary treatment protocols) * History of CNS injury/disease predating or unrelated to cancer diagnosis * Documented ADHD predating cancer diagnosis * Treatment with psychostimulant or psychotropic medication within two weeks of study participation * Major sensory or motor impairment that would preclude valid cognitive testing secondary to inability to complete study procedures (e.g., blindness, paresis, poorly controlled seizures/photosensitive epilepsy, psychosis) Inclusion Criteria for Intervention Phase * Signed screening consents and has undergone screening * Fully evaluable psychological testing results (including IQ \> or = 70) * Age-scaled score on Digit Span, Letter-Number Sequencing or Spatial Span \< 7 OR at least one standard deviation below IQ score * Training aide is available to participate in required sessions * Participant and training aide demonstrate computer proficiency * Participant has access to or will be provided a laptop or home computer with internet connection and speakers * Participant willing to participate in required aspects of computerized intervention * Participant is able to take part in fMRI without sedation Exclusion Criteria for Intervention Phase * Major psychological condition that would preclude completion of protocol intervention (e.g., significant oppositionality, autism spectrum disorder, severe anxiety or depressive symptoms) * Orthodontic appliances that cause MRI distortion or signal loss outside the mouth and sinus area
References
Publications (0)
Data not yet available