Clinical trial · Interventional
Evaluation of Methods for the Determination of Chromogranin A in Routine Blood Samples
NCT01216267CI-TRIAL-00008952completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this study is to compare several methods for measurement of Chromogranin A in their ability to serve as a marker for disease activity in patients with neuroendocrine tumors. Further, in a subgroup, we will determine if taking a proton pump inhibitor affects Chromogranin A levels.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Neuroendocrine Carcinoma (Carcinoid) | Neuroendocrine Carcinoma | ONTOLOGY_EXACT | 0.85 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Lansoprazole | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- ACTIVE_COMPARATOR
- label
- lansoprazole
- description
- lansoprazole for 7 days
- interventionNames
- Drug: Lansoprazole
Primary outcomes (1)
- measure
- chromogranin A concentration serum
- timeFrame
- single time
- description
- For determination of normal CgA range, we will recruit 60 healthy subjects (30 female, 30 male), in whom a single plasma sample will be obtained for measurement of CgA B For determination of CgA in patients with carcinoid disease (active or inactaive), we wil recruit 200 patients with carcinoid disease from our local neuroendocinre oncology clinic.
Secondary outcomes (1)
- measure
- Effect of PPI on chromogranin A concentration
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Patients: Inclusion Criteria: * having neuro-endocrine disease Exclusion Criteria: * age below 18 or above 70 years * prostate cancer * kidney failure (estimated GF \< 30 mL/Min) * heart failure * chronic atrophic gastritis * pregnancy Healthy subjects: Inclusion Criteria: * healthy Exclusion Criteria: * age below 18 or above 70 years * taking any chronic medication (except OCP) * prostate cancer * kidney failure (estimated GFR \< 30 mL/min) * heart failure * pheochromocytoma * islet cell tumors * medullary thyroid cancer * essential hypertension * neurofibromatosis * use of proton pump inhibitors * chronic atrophic gastritis * pregnancy
References
Publications (0)
Data not yet available
No reference posted for this study.