Randomized Trial of Lenalidomide, Bortezomib, Dexamethasone vs High-Dose Treatment With SCT in MM Patients up to Age 65

Inclusion Criteria:

* Diagnosis of Multiple Myeloma, according to the International Myeloma Foundation 2003 Diagnostic Criteria
* Documented symptomatic myeloma, with organ damage related to myeloma with laboratory assessments performed within 21 days of registration
* Myeloma that is measurable by either serum or urine evaluation of the monoclonal component or by assay of serum free light chains.
* ECOG performance status \</= 2
* Negative HIV blood test
* Voluntary written informed consent

Exclusion Criteria:

* Pregnant or lactating female
* Prior systemic therapy for MM (localized radiotherapy allowed if at least 7 days before study entry, corticosteroids allowed if dose \</= equivalent of 160 mg dexamethasone over 2 weeks)
* Primary amyloidosis (AL) or myeloma complicated by amylosis
* Receiving any other investigational agents
* Known brain metastases
* Poor tolerability or allergy to any of the study drugs or compounds of similar composition
* Platelet count \<50,000/mm3, within 21 days of registration
* ANC \<1,000 cells/mm3, within 21 days of registration
* Hemoglobin \<8 g/dL, within 21 days of registration
* Hepatic impairment (\>/= 1.5 x institutional ULN or AST (SGOT), ALT (SGPT), or alkaline phosphatase \>2 x ULN). Patients with benign hyperbilirubinemia are eligible.
* Renal insufficiency (serum creatinine \>2.0 mg/dl or creatinine clearance \<50 ml/min, within 21 days of registration)
* Respiratory compromise (DLCO \< 50%)
* Clinical signs of heart or coronary failure or LVEF \< 40%. Myocardial infarction within 6 months prior to enrollment, NYHA Class III or IV heart failure, uncontrolled angina, severe uncontrolled ventricular arrhythmias, or electrocardiographic evidence of acute ischemia or active conductive system abnormalities
* Intercurrent illness including, but not limited to ongoing or active severe infection, known infection with hepatitis B or C virus, poorly controlled diabetes, severe uncontrolled psychiatric disorder or psychiatric illness/social situations that would limit compliance with study requirements
* Previous history of another malignant condition except for basal cell carcinoma and stage I cervical cancer. If malignancy was experienced more than 2 years ago and confirmed as cured, these participants may be considered for the study on case by case basis with PI discussion.
* Inability to comply with an anti-thrombotic treatment regimen
* Peripheral neuropathy \>/= Grade 2